Osteoblasts are the only cells that can give rise to bones in vertebrates. Thus, one of the
most important functions of these metabolically active cells is mineralized matrix production …

There is a high incidence of fractures in clinical practice and therapy. The repairment of
critical size defects in the skeletal system remains a huge challenge for surgeons and …

Craniosynostosis is a debilitating birth defect characterized by the premature fusion of
cranial bones resulting from premature loss of stem cells located in suture tissue between …

While adult bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs) and their
extrinsic regulation is well studied, little is known about the composition, function, and …

SOX8 was linked in a genome-wide association study to human height heritability, but roles
in chondrocytes for this close relative of the master chondrogenic transcription factor SOX9 …

Background Derivation of osteoblast-like cells from human pluripotent stem cells (hPSCs) is
a popular topic in bone tissue engineering. Although many improvements have been …

Stem cells remain in a quiescent state for long-term maintenance and preservation of
potency; this process requires fine-tuning regulatory mechanisms. In this study, we identified …

The osteogenic microenvironment of bone-repairing materials plays a key role in
accelerating bone regeneration but remains incompletely defined, which significantly limits …

Skeletal stem/progenitor cells (SSPCs), characterized by self-renewal and multipotency, are
essential for skeletal development, bone remodeling, and bone repair. These cells have …

Building and maintaining skeletal tissue requires the activity of skeletal stem and progenitor
cells (SSPCs). Following injury, local pools of these SSPCs become active and coordinate to …