Human immunodeficiency virus type 1 (HIV-1) replication is a highly regulated process
requiring the recruitment of viral and cellular components to the plasma membrane for …

Viruses are obligate parasites that rely on host cellular factors to replicate and spread. The
endosomal sorting complexes required for transport (ESCRT) system, which is classically …

Membraneless biomolecular condensates (BMCs) contribute to the replication of a growing
number of viruses but remain to be functionally characterized. Previously, we demonstrated …

HIV reverse transcription and nucleocapsid. After the capsid has entered the cell, reverse
transcriptase (A) creates a DNA copy (green) of the HIV RNA genome (yellow), using a …

ABSTRACT The Pr55Gag precursor specifically selects the HIV-1 genomic RNA (gRNA)
from a large excess of cellular and partially or fully spliced viral RNAs and drives the virus …

The interactions that occur during HIV Pr55Gag oligomerization and genomic RNA
packaging are essential elements that facilitate HIV assembly. However, mechanistic details …

HIV-1 Gag polyprotein orchestrates the assembly of viral particles. Its C-terminus consists of
the nucleocapsid (NC) domain that interacts with nucleic acids, and p1 and p6, two …

Maturation of the HIV-1 viral particles shortly after budding is required for infectivity. During
this process, the Pr55Gag precursor undergoes a cascade of proteolytic cleavages, and …

ABSTRACT HIV-1 uses cellular machinery to bud from infected cells. This cellular machinery
is comprised of several multiprotein complexes known as endosomal sorting complexes …

The HIV-1 Gag protein playing a key role in HIV-1 viral assembly has recently been shown
to interact through its nucleocapsid domain with the ribosomal protein L7 (RPL7) that acts as …