Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures

V Crunelli, ML Lőrincz, C McCafferty, RC Lambert… - Brain, 2020 - academic.oup.com
Absence seizures in children and teenagers are generally considered relatively benign
because of their non-convulsive nature and the large incidence of remittance in early …

The default mode network and altered consciousness in epilepsy

NB Danielson, JN Guo, H Blumenfeld - Behavioural neurology, 2011 - content.iospress.com
The default mode network has been hypothesized based on the observation that specific
regions of the brain are consistently activated during the resting state and deactivated during …

Impaired consciousness in epilepsy

H Blumenfeld - The Lancet Neurology, 2012 - thelancet.com
Consciousness is essential to normal human life. In epileptic seizures consciousness is
often transiently lost, which makes it impossible for the individual to experience or respond …

Cortical and subcortical networks in human secondarily generalized tonic–clonic seizures

H Blumenfeld, GI Varghese, MJ Purcaro, JE Motelow… - Brain, 2009 - academic.oup.com
Generalized tonic–clonic seizures are among the most dramatic physiological events in the
nervous system. The brain regions involved during partial seizures with secondary …

Impaired consciousness in temporal lobe seizures: role of cortical slow activity

DJ Englot, LI Yang, H Hamid, N Danielson, X Bai… - Brain, 2010 - academic.oup.com
Impaired consciousness requires altered cortical function. This can occur either directly from
disorders that impair widespread bilateral regions of the cortex or indirectly through effects …

Impaired attention and network connectivity in childhood absence epilepsy

BD Killory, X Bai, M Negishi, C Vega, MN Spann… - Neuroimage, 2011 - Elsevier
Patients with childhood absence epilepsy (CAE) often demonstrate impaired interictal
attention, even with control of their seizures. No previous study has investigated the brain …

Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures

C McCafferty, BF Gruenbaum, R Tung, JJ Li… - Nature …, 2023 - nature.com
Absence seizures are brief episodes of impaired consciousness, behavioral arrest, and
unresponsiveness, with yet-unknown neuronal mechanisms. Here we report that an awake …

Focal abnormalities in idiopathic generalized epilepsy: a critical review of the literature

U Seneviratne, M Cook, W D'souza - Epilepsia, 2014 - Wiley Online Library
Conventionally, epilepsy is dichotomized into distinct “focal” and “generalized” categories.
However, many studies have reported so‐called focal features among patients with …

Metabolic modulation of synaptic failure and thalamocortical hypersynchronization with preserved consciousness in Glut1 deficiency

K Rajasekaran, Q Ma, LB Good, G Kathote… - Science translational …, 2022 - science.org
Individuals with glucose transporter type I deficiency (G1D) habitually experience nutrient-
responsive epilepsy associated with decreased brain glucose. However, the mechanistic …

The large-scale functional connectivity correlates of consciousness and arousal during the healthy and pathological human sleep cycle

E Tagliazucchi, EJW van Someren - Neuroimage, 2017 - Elsevier
Advances in neuroimaging have greatly improved our understanding of human sleep from a
systems neuroscience perspective. However, cognition and awareness are reduced during …