Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures
Absence seizures in children and teenagers are generally considered relatively benign
because of their non-convulsive nature and the large incidence of remittance in early …
because of their non-convulsive nature and the large incidence of remittance in early …
The default mode network and altered consciousness in epilepsy
The default mode network has been hypothesized based on the observation that specific
regions of the brain are consistently activated during the resting state and deactivated during …
regions of the brain are consistently activated during the resting state and deactivated during …
Impaired consciousness in epilepsy
H Blumenfeld - The Lancet Neurology, 2012 - thelancet.com
Consciousness is essential to normal human life. In epileptic seizures consciousness is
often transiently lost, which makes it impossible for the individual to experience or respond …
often transiently lost, which makes it impossible for the individual to experience or respond …
Cortical and subcortical networks in human secondarily generalized tonic–clonic seizures
Generalized tonic–clonic seizures are among the most dramatic physiological events in the
nervous system. The brain regions involved during partial seizures with secondary …
nervous system. The brain regions involved during partial seizures with secondary …
Impaired consciousness in temporal lobe seizures: role of cortical slow activity
Impaired consciousness requires altered cortical function. This can occur either directly from
disorders that impair widespread bilateral regions of the cortex or indirectly through effects …
disorders that impair widespread bilateral regions of the cortex or indirectly through effects …
Impaired attention and network connectivity in childhood absence epilepsy
BD Killory, X Bai, M Negishi, C Vega, MN Spann… - Neuroimage, 2011 - Elsevier
Patients with childhood absence epilepsy (CAE) often demonstrate impaired interictal
attention, even with control of their seizures. No previous study has investigated the brain …
attention, even with control of their seizures. No previous study has investigated the brain …
Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures
Absence seizures are brief episodes of impaired consciousness, behavioral arrest, and
unresponsiveness, with yet-unknown neuronal mechanisms. Here we report that an awake …
unresponsiveness, with yet-unknown neuronal mechanisms. Here we report that an awake …
Focal abnormalities in idiopathic generalized epilepsy: a critical review of the literature
Conventionally, epilepsy is dichotomized into distinct “focal” and “generalized” categories.
However, many studies have reported so‐called focal features among patients with …
However, many studies have reported so‐called focal features among patients with …
Metabolic modulation of synaptic failure and thalamocortical hypersynchronization with preserved consciousness in Glut1 deficiency
Individuals with glucose transporter type I deficiency (G1D) habitually experience nutrient-
responsive epilepsy associated with decreased brain glucose. However, the mechanistic …
responsive epilepsy associated with decreased brain glucose. However, the mechanistic …
The large-scale functional connectivity correlates of consciousness and arousal during the healthy and pathological human sleep cycle
E Tagliazucchi, EJW van Someren - Neuroimage, 2017 - Elsevier
Advances in neuroimaging have greatly improved our understanding of human sleep from a
systems neuroscience perspective. However, cognition and awareness are reduced during …
systems neuroscience perspective. However, cognition and awareness are reduced during …