Mendelian randomization
Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes …
address causal questions about how modifiable exposures influence different outcomes …
Mendelian randomization: concepts and scope
RC Richmond, GD Smith - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers
Monitoring the effects of daily activities on the physiological responses of the body calls for
wearable devices that can simultaneously track metabolic and haemodynamic parameters …
wearable devices that can simultaneously track metabolic and haemodynamic parameters …
[HTML][HTML] Guidelines for performing Mendelian randomization investigations: update for summer 2023
This paper provides guidelines for performing Mendelian randomization investigations. It is
aimed at practitioners seeking to undertake analyses and write up their findings, and at …
aimed at practitioners seeking to undertake analyses and write up their findings, and at …
Resistant hypertension: detection, evaluation, and management: a scientific statement from the American Heart Association
Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a
patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a …
patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a …
Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
Mendelian randomisation uses genetic variation as a natural experiment to investigate the
causal relations between potentially modifiable risk factors and health outcomes in …
causal relations between potentially modifiable risk factors and health outcomes in …
Multivariable Mendelian randomization and mediation
E Sanderson - Cold Spring Harbor perspectives …, 2021 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is the use of genetic variants associated with an exposure to
estimate the causal effect of that exposure on an outcome. Mediation analysis is the method …
estimate the causal effect of that exposure on an outcome. Mediation analysis is the method …
Evaluating the potential role of pleiotropy in Mendelian randomization studies
Pleiotropy, the phenomenon of a single genetic variant influencing multiple traits, is likely
widespread in the human genome. If pleiotropy arises because the single nucleotide …
widespread in the human genome. If pleiotropy arises because the single nucleotide …
[HTML][HTML] Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies
Background Low-risk limits recommended for alcohol consumption vary substantially across
different national guidelines. To define thresholds associated with lowest risk for all-cause …
different national guidelines. To define thresholds associated with lowest risk for all-cause …
[HTML][HTML] Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990 …
GBD 2015 Risk Factors Collaborators - Lancet (London, England …, 2016 - ncbi.nlm.nih.gov
Background The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides
an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden …
an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden …