Challenges and advances in clinical applications of mesenchymal stromal cells

T Zhou, Z Yuan, J Weng, D Pei, X Du, C He… - Journal of hematology & …, 2021 - Springer
Mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have been
intensely investigated for clinical applications within the last decades. However, the majority …

Senescence in mesenchymal stem cells: functional alterations, molecular mechanisms, and rejuvenation strategies

J Liu, Y Ding, Z Liu, X Liang - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are multipotent cells capable of self-renewal and
differentiation. There is increasing evidence of the therapeutic value of MSCs in various …

Specificity of 3D MSC spheroids microenvironment: impact on MSC behavior and properties

A Jauković, D Abadjieva, D Trivanović… - Stem cell reviews and …, 2020 - Springer
Mesenchymal stem cells (MSC) have been considered the promising candidates for the
regenerative and personalized medicine due to their self-renewal potential, multilineage …

[HTML][HTML] Mesenchymal stem cells for the management of inflammation in osteoarthritis: state of the art and perspectives

YM Pers, M Ruiz, D Noël, C Jorgensen - Osteoarthritis and cartilage, 2015 - Elsevier
Osteoarthritis (OA) is the most common form of degenerative arthritis, mainly characterized
by the degradation of articular cartilage and associated with subchondral bone lesions …

Stem cells in veterinary medicine—current state and treatment options

M Voga, N Adamic, M Vengust… - Frontiers in veterinary …, 2020 - frontiersin.org
Regenerative medicine is a branch of medicine that develops methods to grow, repair, or
replace damaged or diseased cells, organs or tissues. It has gained significant momentum …

Mesenchymal stromal/stem cells and their exosomes application in the treatment of intervertebral disc disease: A promising frontier

G Widjaja, AT Jalil, HS Budi, WK Abdelbasset… - International …, 2022 - Elsevier
Today, the application of mesenchymal stromal/stem cells (MSCs) and their exosomes to
treat degenerative diseases has received attention. Due to the characteristics of these cells …

Anti-donor immune responses elicited by allogeneic mesenchymal stem cells and their extracellular vesicles: are we still learning?

P Lohan, O Treacy, MD Griffin, T Ritter… - Frontiers in …, 2017 - frontiersin.org
Mesenchymal stromal cells (MSC) have been used to treat a broad range of disease
indications such as acute and chronic inflammatory disorders, autoimmune diseases, and …

[HTML][HTML] Genetically modified mesenchymal stromal cells in cancer therapy

EK Sage, RM Thakrar, SM Janes - Cytotherapy, 2016 - Elsevier
The cell therapy industry has grown rapidly over the past 3 decades, and multiple clinical
trials have been performed to date covering a wide range of diseases. The most frequently …

Increased paracrine immunomodulatory potential of mesenchymal stromal cells in three-dimensional culture

B Follin, M Juhl, S Cohen, AE Pedersen… - … Engineering Part B …, 2016 - liebertpub.com
Mesenchymal stromal/stem cells (MSCs) have been investigated extensively through the
past years, proving to have great clinical therapeutic potential. In vitro cultivation of MSCs in …

3D bioassembly of cell-instructive chondrogenic and osteogenic hydrogel microspheres containing allogeneic stem cells for hybrid biofabrication of osteochondral …

X Cui, CR Alcala-Orozco, K Baer, J Li, CA Murphy… - …, 2022 - iopscience.iop.org
Recently developed modular bioassembly techniques hold tremendous potential in tissue
engineering and regenerative medicine, due to their ability to recreate the complex …