Poorly controlled postoperative pain: prevalence, consequences, and prevention
TJ Gan - Journal of pain research, 2017 - Taylor & Francis
This review provides an overview of the clinical issue of poorly controlled postoperative pain
and therapeutic approaches that may help to address this common unresolved health-care …
and therapeutic approaches that may help to address this common unresolved health-care …
Critical assessment of G protein-biased agonism at the μ-opioid receptor
A Gillis, A Kliewer, E Kelly, G Henderson… - Trends in …, 2020 - cell.com
G protein-biased agonists of the μ-opioid receptor (MOPr) have been proposed as an
improved class of opioid analgesics. Recent studies have been unable to reproduce the …
improved class of opioid analgesics. Recent studies have been unable to reproduce the …
Insights into distinct signaling profiles of the µOR activated by diverse agonists
Drugs targeting the μ-opioid receptor (μOR) are the most effective analgesics available but
are also associated with fatal respiratory depression through a pathway that remains …
are also associated with fatal respiratory depression through a pathway that remains …
Structure-based design of bitopic ligands for the µ-opioid receptor
Mu-opioid receptor (µOR) agonists such as fentanyl have long been used for pain
management, but are considered a major public health concern owing to their adverse side …
management, but are considered a major public health concern owing to their adverse side …
[HTML][HTML] Understanding kratom use: a guide for healthcare providers
Kratom (Mitragyna speciosa Korth., Rubiaceae) is a plant native to Southeast Asia, where it
has been used for centuries as a mild stimulant and as medicine for various ailments. More …
has been used for centuries as a mild stimulant and as medicine for various ailments. More …
Kratom—pharmacology, clinical implications, and outlook: a comprehensive review
SC Eastlack, EM Cornett, AD Kaye - Pain and therapy, 2020 - Springer
Kratom, or Mitragyna, is a tropical plant indigenous to Southeast Asia, with unique
pharmacological properties. It is commonly consumed by preparing the leaves into …
pharmacological properties. It is commonly consumed by preparing the leaves into …
Spirocyclic motifs in natural products
E Chupakhin, O Babich, A Prosekov, L Asyakina… - Molecules, 2019 - mdpi.com
Spirocyclic motifs are emerging privileged structures for drug discovery. They are also
omnipresent in the natural products domain. However, until today, no attempt to analyze the …
omnipresent in the natural products domain. However, until today, no attempt to analyze the …
The medicinal chemistry and neuropharmacology of kratom: A preliminary discussion of a promising medicinal plant and analysis of its potential for abuse
AC Kruegel, O Grundmann - Neuropharmacology, 2018 - Elsevier
The leaves of Mitragyna speciosa (commonly known as kratom), a tree endogenous to parts
of Southeast Asia, have been used traditionally for their stimulant, mood-elevating, and …
of Southeast Asia, have been used traditionally for their stimulant, mood-elevating, and …
Current perspectives on the impact of Kratom use
C Veltri, O Grundmann - Substance abuse and rehabilitation, 2019 - Taylor & Francis
The leaves from the tree Mitragyna speciosa, commonly known as Kratom, in the coffee
plant family (Rubiaceae) are commonly used in their native habitat of Southeast Asia as a …
plant family (Rubiaceae) are commonly used in their native habitat of Southeast Asia as a …
Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions
The safety and efficacy of kratom (Mitragyna speciosa) for treatment of pain is highly
controversial. Kratom produces more than 40 structurally related alkaloids, but most studies …
controversial. Kratom produces more than 40 structurally related alkaloids, but most studies …