NAMI-A and KP1019/1339, two iconic ruthenium anticancer drug candidates face-to-face: A case story in medicinal inorganic chemistry
NAMI-A ((ImH)[trans-RuCl4 (dmso-S)(Im)], Im= imidazole) and KP1019/1339
(KP1019=(IndH)[trans-RuCl4 (Ind) 2], Ind= indazole; KP1339= Na [trans-RuCl4 (Ind) 2]) are …
(KP1019=(IndH)[trans-RuCl4 (Ind) 2], Ind= indazole; KP1339= Na [trans-RuCl4 (Ind) 2]) are …
The development of ruthenium (II) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications
Ruthenium (II)[Ru (II)] polypyridyl complexes have been the focus of intense investigations
since work began exploring their supramolecular interactions with DNA. In recent years …
since work began exploring their supramolecular interactions with DNA. In recent years …
Thirty years of the drug candidate NAMI‐A and the myths in the field of ruthenium anticancer compounds: a personal perspective
E Alessio - European Journal of Inorganic Chemistry, 2017 - Wiley Online Library
As anticipated in the title, this contribution is basically divided into two, strictly connected,
parts. The first is a personal overview of the ruthenium drug candidate NAMI‐A, almost 30 …
parts. The first is a personal overview of the ruthenium drug candidate NAMI‐A, almost 30 …
Synthesis, characterization, crystal structure, DNA and HSA Interactions, and anticancer activity of a mononuclear Cu (II) complex with a Schiff base ligand containing …
SU Parsekar, K Paliwal, P Haldar, PKS Antharjanam… - ACS …, 2022 - ACS Publications
A mononuclear Cu (II) complex [Cu (HL)(o-phen)]· H2O (1)[H3L=, o-phen= 1, 10-
phenanthroline] was isolated from methanol, and its X-ray single-crystal structure was …
phenanthroline] was isolated from methanol, and its X-ray single-crystal structure was …
Molecular mode of action of NKP-1339–a clinically investigated ruthenium-based drug–involves ER-and ROS-related effects in colon carcinoma cell lines
LS Flocke, R Trondl, MA Jakupec, BK Keppler - Investigational new drugs, 2016 - Springer
Abstract Sodium trans-[tetrachloridobis (1 H-indazole) ruthenate (III)](NKP-1339) is a
clinically investigated ruthenium-based metal complex, which shows promising results in …
clinically investigated ruthenium-based metal complex, which shows promising results in …
X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding …
A Bijelic, S Theiner, BK Keppler… - Journal of medicinal …, 2016 - ACS Publications
Ruthenium (III) complexes are promising candidates for anticancer drugs, especially the
clinically studied indazolium trans-[tetrachlorobis (1 H-indazole) ruthenate (III)](KP1019) and …
clinically studied indazolium trans-[tetrachlorobis (1 H-indazole) ruthenate (III)](KP1019) and …
Mechanisms of action of Ru (II) polypyridyl complexes in living cells upon light irradiation
The unique photophysical properties of Ru (II) polypyridyl complexes make them very
attractive candidates as photosensitisers in Photodynamic Therapy (PDT). However, to date …
attractive candidates as photosensitisers in Photodynamic Therapy (PDT). However, to date …
A ruthenium(ii) based photosensitizer and transferrin complexes enhance photo-physical properties, cell uptake, and photodynamic therapy safety and efficacy
P Kaspler, S Lazic, S Forward, Y Arenas… - Photochemical & …, 2016 - Springer
Metal-based photosensitizers are of interest as their absorption and chemical binding
properties can be modified via the use of different ligands. Ru 2+ based photosensitizers are …
properties can be modified via the use of different ligands. Ru 2+ based photosensitizers are …
Novel and versatile imine-N-heterocyclic carbene half-sandwich iridium (III) complexes as lysosome-targeted anticancer agents
Y Yang, L Guo, Z Tian, Y Gong, H Zheng… - Inorganic …, 2018 - ACS Publications
We, herein, report the synthesis, characterization, luminescence properties, anticancer, and
antibacterial activities of a family of novel half-sandwich iridium (III) complexes of the general …
antibacterial activities of a family of novel half-sandwich iridium (III) complexes of the general …
Anticancer ruthenium (III) complexes and Ru (III)-containing nanoformulations: An update on the mechanism of action and biological activity
The great advances in the studies on metal complexes for the treatment of different cancer
forms, starting from the pioneering works on platinum derivatives, have fostered an …
forms, starting from the pioneering works on platinum derivatives, have fostered an …