Osteosarcoma is the most common primary bone cancer in children and young adults.
Limited progress has been made in improving the survival outcomes in patients with …

Reprogramming the immunosuppressive tumor microenvironment by modulating
macrophages holds great promise in tumor immunotherapy. As a class of professional …

Cancer associated fibroblasts (CAFs) and tumor associated macrophages (TAMs) are
among the most important and abundant players of the tumor microenvironment. CAFs as …

Enabling macrophages to phagocytose tumor cells holds great potential for cancer therapy
but suffers from tremendous challenges because the tumor cells upregulate …

Cancer progression is primarily caused by interactions between transformed cells and the
components of the tumor microenvironment (TME). TAMs (tumor-associated macrophages) …

Background Gastric cancer is one of the most common cancers. Peritoneal carcinomatosis
(PC) appears to be the most common pattern of recurrence, and more than half of the GC …

Cancer therapies, including conventional chemotherapy, radiation, and molecularly targeted
agents, can lead to tumor eradication through a variety of mechanisms. In addition to their …

Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with dismal prognosis
due to distant metastasis, even in the early stage. Using RNA sequencing and multiplex …

Microglial phagocytosis of apoptotic debris prevents buildup damage of neighbor neurons
and inflammatory responses. Whereas microglia are very competent phagocytes under …

Chimeric antigen receptor (CAR)-engineered adoptive cell therapy marks a revolution in
cancer treatment based on the highly successful responses to CAR T cell therapy in the …