Vitamin A update: forms, sources, kinetics, detection, function, deficiency, therapeutic use and toxicity

A Carazo, K Macáková, K Matoušová, LK Krčmová… - Nutrients, 2021 - mdpi.com
Vitamin A is a group of vital micronutrients widely present in the human diet. Animal-based
products are a rich source of the retinyl ester form of the vitamin, while vegetables and fruits …

Hypoxia and adipose tissue function and dysfunction in obesity

P Trayhurn - Physiological reviews, 2013 - journals.physiology.org
The rise in the incidence of obesity has led to a major interest in the biology of white adipose
tissue. The tissue is a major endocrine and signaling organ, with adipocytes, the …

Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver

SL Friedman - Physiological reviews, 2008 - journals.physiology.org
The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

AS Plump, JD Smith, T Hayek, K Aalto-Setälä, A Walsh… - Cell, 1992 - cell.com
Summary apoE-deficient mice have been created by homologous recombination in ES cells.
On a low fat, low cholesterol chow diet these animals have plasma cholesterol levels of 494 …

The clinical course of neuromyelitis optica (Devic's syndrome)

DM Wingerchuk, WF Hogancamp, PC O'brien… - Neurology, 1999 - AAN Enterprises
Objectives: To evaluate the spectrum of neuromyelitis optica (NMO), including
characteristics of the index events (optic neuritis [ON]) and myelitis), neuroimaging, CSF …

The lipocalin protein family: structure and function

DR Flower - Biochemical journal, 1996 - portlandpress.com
The lipocalin protein family is a large group of small extracellular proteins. The family
demonstrates great diversity at the sequence level; however, most lipocalins share three …

Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ

P Trayhurn, JH Beattie - Proceedings of the Nutrition Society, 2001 - cambridge.org
The traditional role attributed to white adipose tissue is energy storage, fatty acids being
released when fuel is required. The metabolic role of white fat is, however, complex. For …

Chemistry of the retinoid (visual) cycle

PD Kiser, M Golczak, K Palczewski - Chemical reviews, 2014 - ACS Publications
As succinctly summarized by Wolf, 1 lack of vitamin A (all-trans-retinol) was recognized by
ancient Egyptians as causing a visual deficiency involving the retina and cornea that could …

Overview of retinoid metabolism and function

R Blomhoff, HK Blomhoff - Journal of neurobiology, 2006 - Wiley Online Library
Retinoids (vitamin A) are crucial for most forms of life. In chordates, they have important roles
in the developing nervous system and notochord and many other embryonic structures, as …

A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A

R Kawaguchi, J Yu, J Honda, J Hu, J Whitelegge… - Science, 2007 - science.org
Vitamin A has diverse biological functions. It is transported in the blood as a complex with
retinol binding protein (RBP), but the molecular mechanism by which vitamin A is absorbed …