Since the 1960s and the therapeutic use of hematopoietic stem cells of bone marrow origin,
there has been an increasing interest in the study of undifferentiated progenitors that have …

Remarkable progress has been made in islet transplantation over a span of 40 years. Once
just an experimental curiosity in mice, this therapy has moved forward, and can now provide …

Background Islet transplantation offers the potential to improve glycemic control in a
subgroup of patients with type 1 diabetes mellitus who are disabled by refractory …

Pancreatic islet encapsulation within semi-permeable materials has been proposed for
transplantation therapy of type I diabetes mellitus. Polymer hydrogel networks used for this …

We sought to determine the long‐term outcomes in type 1 diabetic recipients of intraportal
alloislet transplants on a modified immunosuppressive protocol. Six recipients with …

Successful transplantation requires the prevention of allograft rejection and, in the case of
transplantation to treat autoimmune disease, the suppression of autoimmune responses …

Traditional methods for diabetes management require constant and tedious glucose
monitoring (GM) and insulin injections, impacting quality of life. The global diabetic …

Islet transplantation could become an ideal treatment for severe diabetes to prevent
hypoglycemia shock and irreversible diabetic complications, once some of the major and …

Islet transplantation offers improved glucose homeostasis in diabetic patients, but
transplantation of islets is limited by the supply of donor pancreases. Undifferentiated …

Death by apoptosis shapes tissue homeostasis. Apoptotic mechanisms are so universal that
harnessing them for tailored immune intervention would seem challenging; however, the …