Afucosylated IgG responses in humans–structural clues to the regulation of humoral immunity

JJ Oosterhoff, MD Larsen, CE van der Schoot… - Trends in …, 2022 - cell.com
Healthy immune responses require efficient protection without excessive inflammation.
Recent discoveries on the degree of fucosylation of a human N-linked glycan at a conserved …

SARS-CoV-2 infection of phagocytic immune cells and COVID-19 pathology: Antibody-dependent as well as independent cell entry

O Matveeva, Y Nechipurenko, D Lagutkin… - Frontiers in …, 2022 - frontiersin.org
Our review summarizes the evidence that COVID-19 can be complicated by SARS-CoV-2
infection of immune cells. This evidence is widespread and accumulating at an increasing …

mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses …

JS Buhre, T Pongracz, I Künsting, AS Lixenfeld… - Frontiers in …, 2023 - frontiersin.org
Background The new types of mRNA-containing lipid nanoparticle vaccines BNT162b2 and
mRNA-1273 and the adenovirus-based vaccine AZD1222 were developed against SARS …

[HTML][HTML] Repeated COVID-19 mRNA vaccination results in IgG4 class switching and decreased NK cell activation by S1-specific antibodies in older adults

AT Gelderloos, MK Verheul, I Middelhof… - Immunity & …, 2024 - Springer
Previous research has shown that repeated COVID-19 mRNA vaccination leads to a marked
increase of SARS-CoV-2 spike-specific serum antibodies of the IgG4 subclass, indicating far …

GlYcoLISA: antigen-specific and subclass-specific IgG Fc glycosylation analysis based on an immunosorbent assay with an LC–MS readout

D Falck, M Wuhrer - Nature Protocols, 2024 - nature.com
Immunoglobulin G (IgG) fragment crystallizable (Fc) glycosylation modulates effector
functions such as antibody-dependent cellular cytotoxicity and complement-dependent …

Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines

J Van Coillie, T Pongracz, T Šuštić, W Wang, J Nouta… - Iscience, 2023 - cell.com
IgG antibodies are important mediators of vaccine-induced immunity through complement-
and Fc receptor-dependent effector functions. Both are influenced by the composition of the …

[HTML][HTML] Non-neutralizing functions in anti-SARS-CoV-2 IgG antibodies

S Reinig, SR Shih - Biomedical Journal, 2024 - Elsevier
Most individuals infected with or vaccinated against COVID-19 develop antigenic
neutralizing immunoglobulin G (IgG) antibodies against the SARS-CoV-2 spike protein …

Bulk IgG glycosylation predicts COVID-19 severity and vaccine antibody response

MK Ash, PP Bhimalli, BK Cho, BB Mattamana… - Cell reports, 2022 - cell.com
Although vaccination efforts have expanded, there are still gaps in our understanding
surrounding the immune response to SARS-CoV-2. Measuring IgG Fc glycosylation …

The IgG glycome of SARS-CoV-2 infected individuals reflects disease course and severity

SL Siekman, T Pongracz, W Wang, J Nouta… - Frontiers in …, 2022 - frontiersin.org
Immunoglobulin G (IgG) antibodies play an important role in the immune response against
viruses such as SARS-CoV-2. As the effector functions of IgG are modulated by N …

Impact of structural modifications of IgG antibodies on effector functions

T Damelang, M Brinkhaus, TLJ van Osch… - Frontiers in …, 2024 - frontiersin.org
Immunoglobulin G (IgG) antibodies are a critical component of the adaptive immune system,
binding to and neutralizing pathogens and other foreign substances. Recent advances in …