Rapid technological advances have led to the production of different types of biological data
and enabled construction of complex networks with various types of interactions between …

Melanoma has one of the highest somatic mutational burdens among solid malignancies.
Although the rapid progress in genomic research has contributed immensely to our …

Large-scale cancer genomic studies have revealed that the genetic heterogeneity of the
same type of cancer is greater than previously thought. A key question in cancer genomics is …

Motivation As we move toward an era of precision medicine, the ability to predict patient-
specific drug responses in cancer based on molecular information such as gene expression …

Cancer is often driven by the accumulation of genetic alterations, including single nucleotide
variants, small insertions or deletions, gene fusions, copy-number variations, and large …

Precision cancer medicine promises to tailor clinical decisions to patients using genomic
information. Indeed, successes of drugs targeting genetic alterations in tumors, such as …

Breast cancer is the second most frequently occurring form of cancer and is also the second
most lethal cancer in women worldwide. A genetic mutation is one of the key factors that …

The non-receptor tyrosine kinase Fyn-related kinase (FRK) is a member of the BRK family
kinases (BFKs) and is distantly related to the Src family kinases (SFKs). FRK was first …

Prioritizing molecular alterations that act as drivers of cancer remains a crucial bottleneck in
therapeutic development. Here we introduce HIT'nDRIVE, a computational method that …

Abstract Dachshund homolog 1 (DACH1), a key cell fate determination factor, contributes to
tumorigenesis, invasion, metastasis of human breast neoplasm. However, the exact …