M1 aminopeptidase enzymes are a diverse family of metalloenzymes characterized by
conserved structure and reaction specificity. Excluding viruses, M1 aminopeptidases are …

All known organisms encode 20 canonical amino acids by base triplets in the genetic code.
The cellular translational machinery produces proteins consisting mainly of these amino …

Sigmatropic rearrangements, while rare in biology, offer opportunities for the efficient and
selective synthesis of complex chemical motifs. A “P411” serine‐ligated variant of …

Malaria remains a global health problem, and though international efforts for treatment and
eradication have made some headway, the emergence of drug-resistant parasites threatens …

Background Plasmodium falciparum, the causative agent of human malaria, expresses two
aminopeptidases, Pf M1AAP and Pf M17LAP, critical to generating a free amino acid pool …

Plasmodium parasites, the causative agents of malaria, have developed resistance to most
of our current antimalarial therapies, including artemisinin combination therapies which are …

New antimalarial drug candidates that act via novel mechanisms are urgently needed to
combat malaria drug resistance. Here, we describe the multi-omic chemical validation of …

Malaria is an infectious disease causing vast mortality and morbidity worldwide. Although
antimalarial drugs are effective in several parts of the world, there is a serious threat to …

Plasmodium falciparum, the causative agent of malaria, remains a global health threat as
parasites continue to develop resistance to antimalarial drugs used throughout the world …

The malaria parasite Plasmodium falciparum employs two metallo-aminopeptidases, Pf A-
M1 and Pf A-M17, which are essential for parasite survival. Compounds that inhibit the …