The development of ruthenium (II) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications

FE Poynton, SA Bright, S Blasco, DC Williams… - Chemical Society …, 2017 - pubs.rsc.org
Ruthenium (II)[Ru (II)] polypyridyl complexes have been the focus of intense investigations
since work began exploring their supramolecular interactions with DNA. In recent years …

Monomeric and dimeric coordinatively saturated and substitutionally inert Ru (II) polypyridyl complexes as anticancer drug candidates

A Notaro, G Gasser - Chemical Society Reviews, 2017 - pubs.rsc.org
Due to the increasing impact of cancer on worldwide mortality, more and more attention is
being devoted to the investigation of novel anticancer strategies. Among these …

Ruthenium polypyridyl complex bound to a unimolecular chair-form G-quadruplex

KT McQuaid, S Takahashi… - Journal of the …, 2022 - ACS Publications
The DNA G-quadruplex is known for forming a range of topologies and for the observed
lability of the assembly, consistent with its transient formation in live cells. The stabilization of …

Three's a crowd–stabilisation, structure, and applications of DNA triplexes

M Dalla Pozza, A Abdullrahman, CJ Cardin… - Chemical …, 2022 - pubs.rsc.org
DNA is a strikingly flexible molecule and can form a variety of secondary structures,
including the triple helix, which is the subject of this review. The DNA triplex may be formed …

Increasing the π-expansive ligands in ruthenium (II) polypyridyl complexes: synthesis, characterization, and biological evaluation for photodynamic therapy …

MD Pozza, P Mesdom, A Abdullrahman… - Inorganic …, 2023 - ACS Publications
Lack of selectivity is one of the main issues with currently used chemotherapies, causing
damage not only to altered cells but also to healthy cells. Over the last decades …

A dinuclear ruthenium (II) complex excited by near-infrared light through two-photon absorption induces phototoxicity deep within hypoxic regions of melanoma cancer …

A Raza, SA Archer, SD Fairbanks… - Journal of the …, 2020 - ACS Publications
The dinuclear photo-oxidizing RuII complex [{Ru (TAP2)} 2 (tpphz)] 4+(TAP= 1, 4, 5, 8-
tetraazaphenanthrene, tpphz= tetrapyrido [3, 2-a: 2′, 3′-c: 3 ″, 2′′-h: 2‴, 3′′′-j] …

Good Vibrations Report on the DNA Quadruplex Binding of an Excited State Amplified Ruthenium Polypyridyl IR Probe

M Stitch, D Avagliano, D Graczyk, IP Clark… - Journal of the …, 2023 - ACS Publications
The nitrile containing Ru (II) polypyridyl complex [Ru (phen) 2 (11, 12-dCN-dppz)] 2+(1) is
shown to act as a sensitive infrared probe of G-quadruplex (G4) structures. UV–visible …

Adenine radical cation formation by a ligand-centered excited state of an intercalated chromium polypyridyl complex leads to enhanced DNA photo-oxidation

FA Baptista, D Krizsan, M Stitch… - Journal of the …, 2021 - ACS Publications
Assessment of the DNA photo-oxidation and synthetic photocatalytic activity of chromium
polypyridyl complexes is dominated by consideration of their long-lived metal-centered …

The synthesis and antibacterial activity study of ruthenium-based metallodrugs with a membrane-disruptive mechanism against Staphylococcus aureus

Y Chen, L Liu, X Wang, Z Liao, R Wang, Y Xiong… - Dalton …, 2022 - pubs.rsc.org
The wide spread of drug-resistant bacteria, especially methicillin-resistant Staphylococcus
aureus (MRSA), poses a tremendous threat to global health. Of particular concern …

Whither second-sphere coordination?

W Liu, PJ Das, HM Colquhoun, JF Stoddart - CCS Chemistry, 2022 - chinesechemsoc.org
The properties of coordination complexes are dictated by both the metals and the ligands.
The use of molecular receptors as second-sphere ligands enables significant modulation of …