Enhancers are cis-regulatory elements that can stimulate gene expression from distance,
and drive precise spatiotemporal gene expression profiles during development. Functional …

Human overgrowth disorders are characterized by excessive prenatal and/or postnatal
growth of various tissues. These disorders often present with tall stature, macrocephaly …

Nuclear receptor-binding SET-domain protein 1 (NSD1), a methyltransferase that catalyzes
H3K36me2, is essential for mammalian development and is frequently dysregulated in …

During postnatal development, the DNA methyltransferase DNMT3A deposits high levels of
non-CG cytosine methylation in neurons. This methylation is critical for transcriptional …

The insulator model explains the workings of the H19 and Igf2 imprinted domain in the
soma, where insulation of the Igf2 promoter from its enhancers occurs by CTCF in the …

DNA and Histone 3 Lysine 27 methylation typically function as repressive modifications and
operate within distinct genomic compartments. In mammals, the majority of the genome is …

Epigenetics, the inheritance of genomic information independent of DNA sequence, controls
the interpretation of extracellular and intracellular signals in cell homeostasis, proliferation …

Breast cancer, the most frequent cancer in women, is generally classified into several
distinct histological and molecular subtypes. However, single-cell technologies have …

Histone H3 lysine36 dimethylation (H3K36me2) is generally distributed in the gene body
and euchromatic intergenic regions. However, we found that H3K36me2 is enriched in …

Transposable elements constitute a substantial portion of most eukaryotic genomes and
their activity can lead to developmental and neuronal defects. In the germline, transposon …