The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis

CF Wright, H Burton - Human reproduction update, 2009 - academic.oup.com
BACKGROUND Cell-free fetal nucleic acids (cffNA) can be detected in the maternal
circulation during pregnancy, potentially offering an excellent method for early non-invasive …

Circulating fetal DNA: its origin and diagnostic potential—a review

DW Bianchi - Placenta, 2004 - Elsevier
OBJECTIVE: In contrast to the traditional teaching that the placenta forms an impermeable
barrier, multiple studies show that both intact fetal cells and cell-free nucleic acids circulate …

Effects of blood-processing protocols on fetal and total DNA quantification in maternal plasma

RWK Chiu, LLM Poon, TK Lau, TN Leung… - Clinical …, 2001 - academic.oup.com
Background: Recently, apoptotic cells have been found in plasma obtained by centrifugation
of blood from pregnant women, raising the question of what constitutes plasma and whether …

Size separation of circulatory DNA in maternal plasma permits ready detection of fetal DNA polymorphisms

Y Li, B Zimmermann, C Rusterholz, A Kang… - Clinical …, 2004 - academic.oup.com
Background: Analysis of fetal DNA in maternal plasma has recently been introduced as a
new method for noninvasive prenatal diagnosis, particularly for the analysis of fetal genetic …

Methods for detection of genetic disorders

RS Dhallan - US Patent 7,727,720, 2010 - Google Patents
First worldwide family litigation filed litigation https://patents. darts-ip. com/? family=
46322521&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Detection of the placental epigenetic signature of the maspin gene in maternal plasma

SSC Chim, YK Tong, RWK Chiu… - Proceedings of the …, 2005 - National Acad Sciences
The discovery of fetal DNA in the plasma of pregnant women has opened up new
approaches for noninvasive prenatal diagnosis and monitoring. Up to now, the lack of a fetal …

Methods for detection of genetic disorders

RS Dhallan - US Patent 7,332,277, 2008 - Google Patents
First worldwide family litigation filed litigation https://patents. darts-ip. com/? family=
35375636&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Differential DNA methylation between fetus and mother as a strategy for detecting fetal DNA in maternal plasma

LLM Poon, TN Leung, TK Lau, KCK Chow… - Clinical …, 2002 - academic.oup.com
Background: Fetal DNA has been detected in maternal plasma by the use of genetic
differences between mother and fetus. We explore the possibility of using epigenetic …

Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms

AT Mitchell, M Mitchell - US Patent 7,799,531, 2010 - Google Patents
US7799531B2 - Detecting fetal chromosomal abnormalities using tandem single nucleotide
polymorphisms - Google Patents US7799531B2 - Detecting fetal chromosomal abnormalities …

Circulating nucleic acids and apoptosis

AV Lichtenstein, HS Melkonyan… - Annals of the New …, 2001 - Wiley Online Library
It is well documented that plasma contains DNA from tissues throughout the body, including
developing fetuses, and tumors. A portion of this DNA crosses the kidney barrier and …