[HTML][HTML] Accelerating antiviral drug discovery: lessons from COVID-19
During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and
collaborative drug discovery efforts took place in academia and industry, culminating in …
collaborative drug discovery efforts took place in academia and industry, culminating in …
HIV-1 assembly, budding, and maturation
WI Sundquist, HG Kräusslich - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
A defining property of retroviruses is their ability to assemble into particles that can leave
producer cells and spread infection to susceptible cells and hosts. Virion morphogenesis …
producer cells and spread infection to susceptible cells and hosts. Virion morphogenesis …
An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation
Immature HIV-1 assembles at and buds from the plasma membrane before proteolytic
cleavage of the viral Gag polyprotein induces structural maturation. Maturation can be …
cleavage of the viral Gag polyprotein induces structural maturation. Maturation can be …
[HTML][HTML] The structural biology of HIV-1: mechanistic and therapeutic insights
A Engelman, P Cherepanov - Nature Reviews Microbiology, 2012 - nature.com
Three-dimensional molecular structures can provide detailed information on biological
mechanisms and, for cases in which the molecular function affects human health, can …
mechanisms and, for cases in which the molecular function affects human health, can …
[HTML][HTML] Potential resistance of SARS-CoV-2 main protease (Mpro) against protease inhibitors: lessons learned from HIV-1 protease
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome 2
(SARS-CoV-2), has been one of the most devastating pandemics of recent times. The lack of …
(SARS-CoV-2), has been one of the most devastating pandemics of recent times. The lack of …
SARS-CoV-2 Mpro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals
The main protease of SARS-CoV-2 (Mpro) is the most promising drug target against
coronaviruses due to its essential role in virus replication. With newly emerging variants …
coronaviruses due to its essential role in virus replication. With newly emerging variants …
Fifteen years of HIV Protease Inhibitors: raising the barrier to resistance
AMJ Wensing, NM van Maarseveen, M Nijhuis - Antiviral research, 2010 - Elsevier
HIV protease plays a crucial role in the viral life cycle and is essential for the generation of
mature infectious virus particles. Detailed knowledge of the structure of HIV protease and its …
mature infectious virus particles. Detailed knowledge of the structure of HIV protease and its …
The molecular origin of enthalpy/entropy compensation in biomolecular recognition
Biomolecular recognition can be stubborn; changes in the structures of associating
molecules, or the environments in which they associate, often yield compensating changes …
molecules, or the environments in which they associate, often yield compensating changes …
[HTML][HTML] Current perspectives on HIV-1 antiretroviral drug resistance
P Iyidogan, KS Anderson - Viruses, 2014 - mdpi.com
Current advancements in antiretroviral therapy (ART) have turned HIV-1 infection into a
chronic and manageable disease. However, treatment is only effective until HIV-1 develops …
chronic and manageable disease. However, treatment is only effective until HIV-1 develops …
A copper (I)-catalyzed 1, 2, 3-triazole azide− alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant
MJ Giffin, H Heaslet, A Brik, YC Lin… - Journal of medicinal …, 2008 - ACS Publications
Treatment with HIV-1 protease inhibitors, a component of highly active antiretroviral therapy
(HAART), often results in viral resistance. Structural and biochemical characterization of a …
(HAART), often results in viral resistance. Structural and biochemical characterization of a …