[HTML][HTML] Immunoglobulin G glycosylation in aging and diseases
Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …
a significant degree of variation within populations. IgG glycome composition is influenced …
Molecular boronic acid-based saccharide sensors
GT Williams, JL Kedge, JS Fossey - ACS sensors, 2021 - ACS Publications
Boronic acids can reversibly bind diols, a molecular feature that is ubiquitous within
saccharides, leading to their use in the design and implementation of sensors for numerous …
saccharides, leading to their use in the design and implementation of sensors for numerous …
[HTML][HTML] Hallmarks of glycosylation in cancer
J Munkley, DJ Elliott - Oncotarget, 2016 - ncbi.nlm.nih.gov
Aberrant glycosylation plays a fundamental role in key pathological steps of tumour
development and progression. Glycans have roles in cancer cell signalling, tumour cell …
development and progression. Glycans have roles in cancer cell signalling, tumour cell …
[HTML][HTML] Glycans in the immune system and the altered glycan theory of autoimmunity: a critical review
E Maverakis, K Kim, M Shimoda, ME Gershwin… - Journal of …, 2015 - Elsevier
Herein we will review the role of glycans in the immune system. Specific topics covered
include: the glycosylation sites of IgE, IgM, IgD, IgE, IgA, and IgG; how glycans can encode …
include: the glycosylation sites of IgE, IgM, IgD, IgE, IgA, and IgG; how glycans can encode …
Glycans and glycoproteins as specific biomarkers for cancer
Protein glycosylation and other post-translational modifications are involved in potentially all
aspects of human growth and development. Defective glycosylation has adverse effects on …
aspects of human growth and development. Defective glycosylation has adverse effects on …
[HTML][HTML] IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy
S Shkunnikova, A Mijakovac, L Sironic, M Hanic… - Biotechnology …, 2023 - Elsevier
Immunoglobulin (IgG) glycosylation is a complex enzymatically controlled process, essential
for the structure and function of IgG. IgG glycome is relatively stable in the state of …
for the structure and function of IgG. IgG glycome is relatively stable in the state of …
Glycans as cancer biomarkers
B Adamczyk, T Tharmalingam, PM Rudd - Biochimica et Biophysica Acta …, 2012 - Elsevier
BACKGROUND: Non-invasive biomarkers, such as those from serum, are ideal for disease
prognosis, staging and monitoring. In the past decade, our understanding of the importance …
prognosis, staging and monitoring. In the past decade, our understanding of the importance …
[HTML][HTML] Glycan labeling strategies and their use in identification and quantification
Most methods for the analysis of oligosaccharides from biological sources require a glycan
derivatization step: glycans may be derivatized to introduce a chromophore or fluorophore …
derivatization step: glycans may be derivatized to introduce a chromophore or fluorophore …
A general approach to convert hemicyanine dyes into highly optimized photoacoustic scaffolds for analyte sensing
SH Gardner, CJ Brady, C Keeton… - Angewandte Chemie …, 2021 - Wiley Online Library
Most photoacoustic (PA) imaging agents are based on the repurposing of existing
fluorescent dye platforms that exhibit non‐optimal properties for PA applications. Herein, we …
fluorescent dye platforms that exhibit non‐optimal properties for PA applications. Herein, we …
High-sensitivity analytical approaches for the structural characterization of glycoproteins
1.1. General Considerations Structural intricacies of carbohydrate molecules and their
propensity to form varied linkages, substitutions, and branching patterns have fascinated …
propensity to form varied linkages, substitutions, and branching patterns have fascinated …