Type 1 diabetes mellitus (T1DM) is an autoimmune disease arising through a complex
interaction of both genetic and immunologic factors. Similar to the majority of autoimmune …

Type 1 diabetes mellitus (T1DM) is the archetypal example of a T cell‐mediated
autoimmune disease characterized by selective destruction of pancreatic β cells. The …

Pathogenic T helper cells (Th cells) that respond to self‐antigen cannot be easily
distinguished from beneficial Th cells. These cells can generate systemic autoimmune …

Background IMCY-0098, a synthetic peptide developed to halt disease progression via
elimination of key immune cells in the autoimmune cascade, has shown a promising safety …

In the last 3 years, the association of thyrotropin receptor gene (TSHR) variations to Graves'
disease (GD) has been confirmed. It is now well established that a 30 Kb region of intron 1 of …

Immunological self/non‐self‐discrimination is conventionally seen as an extracellular event,
involving interactions been receptors on T cells pre‐educated to discriminate and peptides …

Phase Ib clinical trial of IMCY-0098 in young adults with recent-onsent type 1 diabetes Page 1
Phase Ib clinical trial of IMCY-0098 in young adults with recent-onset type 1 diabetes J. Van …

Autoimmune diseases are disorders in which the immune system attacks the body's own
tissues. These include type 1 diabetes (T1D) and rheumatoid arthritis (RA) in which the …

This dissertation describes a protective effect on autoimmune diabetes in NOD. scid
recipients following injections of splenocytes from diabetic NOD donors in addition to …

Cytotoxic T-lymphocyte-associated protein 4 (CTLA4) is a protein receptor that
downregulates the immune system. CTLA4 gene variants associate with various …