Exosomes: Therapy delivery tools and biomarkers of diseases

L Barile, G Vassalli - Pharmacology & therapeutics, 2017 - Elsevier
Virtually all cells in the organism secrete extracellular vesicles (EVs), a heterogeneous
population of lipid bilayer membrane-enclosed vesicles that transport and deliver payloads …

Extracellular vesicles in angiogenesis

D Todorova, S Simoncini, R Lacroix, F Sabatier… - Circulation …, 2017 - Am Heart Assoc
During the past decade, extracellular vesicles (EVs), which include apoptotic bodies,
microvesicles, and exosomes, have emerged as important players in cell-to-cell …

Applying extracellular vesicles based therapeutics in clinical trials–an ISEV position paper

T Lener, M Gimona, L Aigner, V Börger… - Journal of …, 2015 - Taylor & Francis
Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different
cell types and participate in physiological and pathophysiological processes. EVs mediate …

Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European …

JPG Sluijter, SM Davidson, CM Boulanger… - Cardiovascular …, 2018 - academic.oup.com
Extracellular vesicles (EVs)—particularly exosomes and microvesicles (MVs)—are attracting
considerable interest in the cardiovascular field as the wide range of their functions is …

Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy

S Kourembanas - Annual review of physiology, 2015 - annualreviews.org
Mesenchymal stem cells (MSCs), whose mechanism of action is predominantly paracrine,
are being widely tested for the treatment of a variety of human diseases. No one factor has …

Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy

Y Lee, S El Andaloussi, MJA Wood - Human molecular genetics, 2012 - academic.oup.com
Exosomes and microvesicles are extracellular nanovesicles released by most but not all
cells. They are specifically equipped to mediate intercellular communication via the transfer …

MSC-exosome: a novel cell-free therapy for cutaneous regeneration

P Wu, B Zhang, H Shi, H Qian, W Xu - Cytotherapy, 2018 - Elsevier
Cutaneous regeneration is a dynamic and complex process that requires a series of
coordinated interactions involving epidermal cells, dermal cells, growth factors, the …

Exosomes as biomimetic tools for stem cell differentiation: applications in dental pulp tissue regeneration

CC Huang, R Narayanan, S Alapati, S Ravindran - Biomaterials, 2016 - Elsevier
Achieving and maintaining safe and reliable lineage specific differentiation of stem cells is
important for clinical translation of tissue engineering strategies. In an effort to circumvent the …

[HTML][HTML] Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury

Y Zhou, P Li, AJ Goodwin, JA Cook, PV Halushka… - Critical Care, 2019 - Springer
Background The acute respiratory distress syndrome (ARDS) is characterized by disruption
of the alveolar-capillary barrier resulting in accumulation of proteinaceous edema and …

Evidence-based clinical use of nanoscale extracellular vesicles in nanomedicine

S Fais, L O'Driscoll, FE Borras, E Buzas, G Camussi… - 2016 - ACS Publications
Recent research has demonstrated that all body fluids assessed contain substantial
amounts of vesicles that range in size from 30 to 1000 nm and that are surrounded by …