The SWI/SNF complexes, initially identified in yeast 20 years ago, are a family of multi-
subunit complexes that use the energy of adenosine triphosphate (ATP) hydrolysis to …

The chromatin remodeler SMARCA4/BRG1 is a key epigenetic regulator with diverse roles
in coordinating the molecular programs that underlie brain tumour development. BRG1 …

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is the most common
undifferentiated ovarian malignancy in women under 40 years of age. We sequenced the …

While investigating cohorts of unclassified sarcomas by RNA sequencing, we identified 19
cases with inactivation of SMARCA4, which encodes an ATPase subunit of BAF chromatin …

Gorlin syndrome and rhabdoid tumor predisposition syndrome (RTPS) are autosomal
dominant syndromes associated with an increased risk of childhood-onset brain tumors …

Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and highly
aggressive ovarian malignancy. In almost all cases, it is associated with somatic and often …

Small cell carcinoma of the ovary, hypercalcaemic type (SCCOHT) is a lethal and sometimes
familial ovarian tumour of young women and children. We and others recently discovered …

Martin Hasselblatt· Inga Nagel· Florian Oyen· Kerstin Bartelheim· Robert B. Russell· Ulrich
Schüller· Reimar Junckerstorff· Marc Rosenblum· Ali H. Alassiri· Sabrina Rossi· Irene …

The identification of mutations and deletions in the SMARCB1 locus in chromosome band
22q11. 2 in pediatric rhabdoid tumors provided the first evidence for the involvement of the …

Deficiency of SMARCA4, a member of the SWI/SNF chromatin remodeling complex, has
been described in a subset of undifferentiated gastroesophageal carcinomas with an …