Monkeypox: disease epidemiology, host immunity and clinical interventions
Monkeypox virus (MPXV), which causes disease in humans, has for many years been
restricted to the African continent, with only a handful of sporadic cases in other parts of the …
restricted to the African continent, with only a handful of sporadic cases in other parts of the …
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
NF-κB: at the borders of autoimmunity and inflammation
L Barnabei, E Laplantine, W Mbongo… - Frontiers in …, 2021 - frontiersin.org
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …
Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression
Glioblastoma (GBM), a highly lethal brain cancer, is notorious for immunosuppression, but
the mechanisms remain unclear. Here, we documented a temporospatial patterning of tumor …
the mechanisms remain unclear. Here, we documented a temporospatial patterning of tumor …
Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention
S Mirzaei, MDA Paskeh, E Okina, MH Gholami… - Journal of Experimental …, 2022 - Springer
Background One of the most malignant tumors in men is prostate cancer that is still incurable
due to its heterogenous and progressive natures. Genetic and epigenetic changes play …
due to its heterogenous and progressive natures. Genetic and epigenetic changes play …
The role and therapeutic potential of NF-kappa-B pathway in severe COVID-19 patients
A Hariharan, AR Hakeem, S Radhakrishnan… - …, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) pandemic has affected health care systems
worldwide. Severe presentations of COVID-19 such as severe pneumonia and acute …
worldwide. Severe presentations of COVID-19 such as severe pneumonia and acute …
YTHDF2 inhibition potentiates radiotherapy antitumor efficacy
Summary RNA N 6-methyladenosine (m 6 A) modification is implicated in cancer
progression. However, the impact of m 6 A on the antitumor effects of radiotherapy and the …
progression. However, the impact of m 6 A on the antitumor effects of radiotherapy and the …
Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy
Malignant transformation and tumour progression are associated with cancer-cell softening.
Yet how the biomechanics of cancer cells affects T-cell-mediated cytotoxicity and thus the …
Yet how the biomechanics of cancer cells affects T-cell-mediated cytotoxicity and thus the …
Genistein: A review on its anti-inflammatory properties
Nowadays, non-resolving inflammation is becoming a major trigger in various diseases as it
plays a significant role in the pathogenesis of atherosclerosis, asthma, cancer, obesity …
plays a significant role in the pathogenesis of atherosclerosis, asthma, cancer, obesity …
Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update
Respiratory disorders, especially non-communicable, chronic inflammatory diseases, are
amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases …
amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases …