Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

The discovery of novel small-molecule antibacterial drugs has been stalled for many years.
The purpose of this review is to underscore and illustrate those scientific problems unique to …

Gram-negative bacteria surround their cytoplasmic membrane with a peptidoglycan (PG)
cell wall and an outer membrane (OM) with an outer leaflet composed of lipopolysaccharide …

Colistin is an antibiotic of last resort, but has poor efficacy and resistance is a growing
problem. Whilst it is well established that colistin disrupts the bacterial outer membrane (OM) …

The lipid A moiety of lipopolysaccharide forms the outer monolayer of the outer membrane of
most gram-negative bacteria. Escherichia coli lipid A is synthesized on the cytoplasmic …

Infections with Pseudomonas aeruginosa have become a concerning threat in hospital-
acquired infections and for cystic fibrosis patients. The major problem leading to high …

Gram-negative bacteria are responsible for an increasing number of deaths caused by
antibiotic-resistant infections,. The bacterial natural product colistin is considered the last …

In many Gram‐negative bacteria, lipopolysaccharide (LPS) and its lipid A moiety are pivotal
for bacterial survival. Depending on its structure, lipid A carries the toxic properties of the …

Conjugated poly-ynes and poly (metalla-ynes) constitute an important class of new materials
with potential application in various domains of science. The key factors responsible for the …

Determining the chemical composition of biological materials is paramount to the study of
natural phenomena. Here, we describe the composition of model gram-negative outer …