Iron is biologically essential, but also potentially toxic; as such it is tightly controlled at cell
and systemic levels to prevent both deficiency and overload. Iron regulatory proteins post …

Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of
intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which …

In vertebrates, transferrin (Tf) safely delivers iron through circulation to cells. Tf-bound iron is
incorporated through Tf receptor (TfR) 1-mediated endocytosis. TfR1 can mediate cellular …

Host microbiota crosstalk is essential for the production and functional modulation of blood-
cell lineages. Whether, and if so how, the microbiota influences hematopoietic stem cells …

Abstract The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-
dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis …

The erythroid marrow and circulating red blood cells (RBCs) are the key components of the
human erythron. Abnormalities of the erythron that are responsible for anemia can be …

Hepcidin is central to regulation of iron metabolism. Its effect on a cellular level involves
binding ferroportin, the main iron export protein, resulting in its internalization and …

Beta-thalassaemia causes defective haemoglobin synthesis leading to ineffective
erythropoiesis, chronic haemolytic anaemia, and subsequent clinical complications. Blood …

Abstract β-Thalassemia (BT) is an inherited genetic disorder that is characterized by
ineffective erythropoiesis (IE), leading to anemia and abnormal iron metabolism. IE is an …

As essential components of hemoglobin, iron and heme play central roles in terminal
erythropoiesis. The impairment of this process in iron/heme deficiency results in microcytic …