Cannabis and synaptic reprogramming of the developing brain
Recent years have been transformational in regard to the perception of the health risks and
benefits of cannabis with increased acceptance of use. This has unintended …
benefits of cannabis with increased acceptance of use. This has unintended …
Hippocampal GABAergic inhibitory interneurons
KA Pelkey, R Chittajallu, MT Craig… - Physiological …, 2017 - journals.physiology.org
In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …
of the total neuronal population; however, their remarkable anatomical and physiological …
Cannabis and the developing brain: insights into its long-lasting effects
YL Hurd, OJ Manzoni, MV Pletnikov, FS Lee… - Journal of …, 2019 - Soc Neuroscience
The recent shift in sociopolitical debates and growing liberalization of cannabis use across
the globe has raised concern regarding its impact on vulnerable populations, such as …
the globe has raised concern regarding its impact on vulnerable populations, such as …
Δ9-tetrahydrocannabinol exposure during rat pregnancy leads to symmetrical fetal growth restriction and labyrinth-specific vascular defects in the placenta
BV Natale, KN Gustin, K Lee, AC Holloway… - Scientific reports, 2020 - nature.com
Abstract 1 in 5 women report cannabis use during pregnancy, with nausea cited as their
primary motivation. Studies show that (-)-△ 9–tetrahydrocannabinol (Δ9-THC), the major …
primary motivation. Studies show that (-)-△ 9–tetrahydrocannabinol (Δ9-THC), the major …
Sex-dependent effects of in utero cannabinoid exposure on cortical function
A Bara, A Manduca, A Bernabeu, M Borsoi, M Serviado… - Elife, 2018 - elifesciences.org
Cannabinoids can cross the placenta, thus may interfere with fetal endocannabinoid
signaling during neurodevelopment, causing long-lasting deficits. Despite increasing reports …
signaling during neurodevelopment, causing long-lasting deficits. Despite increasing reports …
Prenatal cannabinoid exposure: emerging evidence of physiological and neuropsychiatric abnormalities
Clinical reports of cannabis use prevalence during pregnancy vary widely from 3% to
upwards of 35% in North America; this disparity likely owing to underestimates from self …
upwards of 35% in North America; this disparity likely owing to underestimates from self …
Consequences of perinatal cannabis exposure
AF Scheyer, M Melis, V Trezza, OJJ Manzoni - Trends in neurosciences, 2019 - cell.com
Cannabis exposure during the perinatal period results in varied and significant
consequences in affected offspring. The prevalence of detrimental outcomes of perinatal …
consequences in affected offspring. The prevalence of detrimental outcomes of perinatal …
Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring
R Schrott, JL Modliszewski, AB Hawkey… - Epigenetics & …, 2022 - Springer
Background Cannabis legalization is expanding and men are the predominant users. We
have limited knowledge about how cannabis impacts sperm and whether the effects are …
have limited knowledge about how cannabis impacts sperm and whether the effects are …
Prenatal THC exposure induces long-term, sex-dependent cognitive dysfunction associated with lipidomic and neuronal pathology in the prefrontal cortex …
MH Sarikahya, SL Cousineau, M De Felice… - Molecular …, 2023 - nature.com
With increasing maternal cannabis use, there is a need to investigate the lasting impact of
prenatal exposure to Δ9-tetrahydrocannabinol (THC), the main psychotropic compound in …
prenatal exposure to Δ9-tetrahydrocannabinol (THC), the main psychotropic compound in …
Cannabis exposure during critical windows of development: epigenetic and molecular pathways implicated in neuropsychiatric disease
Abstract Purpose of Review Cannabis exposure during critical windows of development may
have intergenerational physiological consequences disrupting epigenetic programming and …
have intergenerational physiological consequences disrupting epigenetic programming and …