Cannabis and synaptic reprogramming of the developing brain

A Bara, JMN Ferland, G Rompala, H Szutorisz… - Nature Reviews …, 2021 - nature.com
Recent years have been transformational in regard to the perception of the health risks and
benefits of cannabis with increased acceptance of use. This has unintended …

Hippocampal GABAergic inhibitory interneurons

KA Pelkey, R Chittajallu, MT Craig… - Physiological …, 2017 - journals.physiology.org
In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Cannabis and the developing brain: insights into its long-lasting effects

YL Hurd, OJ Manzoni, MV Pletnikov, FS Lee… - Journal of …, 2019 - Soc Neuroscience
The recent shift in sociopolitical debates and growing liberalization of cannabis use across
the globe has raised concern regarding its impact on vulnerable populations, such as …

Δ9-tetrahydrocannabinol exposure during rat pregnancy leads to symmetrical fetal growth restriction and labyrinth-specific vascular defects in the placenta

BV Natale, KN Gustin, K Lee, AC Holloway… - Scientific reports, 2020 - nature.com
Abstract 1 in 5 women report cannabis use during pregnancy, with nausea cited as their
primary motivation. Studies show that (-)-△ 9–tetrahydrocannabinol (Δ9-THC), the major …

Sex-dependent effects of in utero cannabinoid exposure on cortical function

A Bara, A Manduca, A Bernabeu, M Borsoi, M Serviado… - Elife, 2018 - elifesciences.org
Cannabinoids can cross the placenta, thus may interfere with fetal endocannabinoid
signaling during neurodevelopment, causing long-lasting deficits. Despite increasing reports …

Prenatal cannabinoid exposure: emerging evidence of physiological and neuropsychiatric abnormalities

MG Nashed, DB Hardy, SR Laviolette - Frontiers in psychiatry, 2021 - frontiersin.org
Clinical reports of cannabis use prevalence during pregnancy vary widely from 3% to
upwards of 35% in North America; this disparity likely owing to underestimates from self …

Consequences of perinatal cannabis exposure

AF Scheyer, M Melis, V Trezza, OJJ Manzoni - Trends in neurosciences, 2019 - cell.com
Cannabis exposure during the perinatal period results in varied and significant
consequences in affected offspring. The prevalence of detrimental outcomes of perinatal …

Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring

R Schrott, JL Modliszewski, AB Hawkey… - Epigenetics & …, 2022 - Springer
Background Cannabis legalization is expanding and men are the predominant users. We
have limited knowledge about how cannabis impacts sperm and whether the effects are …

Prenatal THC exposure induces long-term, sex-dependent cognitive dysfunction associated with lipidomic and neuronal pathology in the prefrontal cortex …

MH Sarikahya, SL Cousineau, M De Felice… - Molecular …, 2023 - nature.com
With increasing maternal cannabis use, there is a need to investigate the lasting impact of
prenatal exposure to Δ9-tetrahydrocannabinol (THC), the main psychotropic compound in …

Cannabis exposure during critical windows of development: epigenetic and molecular pathways implicated in neuropsychiatric disease

A Smith, F Kaufman, MS Sandy, A Cardenas - Current environmental …, 2020 - Springer
Abstract Purpose of Review Cannabis exposure during critical windows of development may
have intergenerational physiological consequences disrupting epigenetic programming and …