[HTML][HTML] EMT, cancer stem cells and autophagy; The three main axes of metastasis

G Babaei, SGG Aziz, NZZ Jaghi - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Epithelial-mesenchymal transition (EMT) and Cancer stem-like cells (CSCs) are major
factors contributing to the metastasis of cancer cells. Consequently, the signaling pathways …

New and emerging targeted therapies for advanced breast cancer

KH Lau, AM Tan, Y Shi - International journal of molecular sciences, 2022 - mdpi.com
In the United States, breast cancer is among the most frequently diagnosed cancers in
women. Breast cancer is classified into four major subtypes: human epidermal growth factor …

Pathological implication of protein post-translational modifications in cancer

S Pan, R Chen - Molecular aspects of medicine, 2022 - Elsevier
Protein post-translational modifications (PTMs) profoundly influence protein functions and
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …

How the Warburg effect supports aggressiveness and drug resistance of cancer cells?

P Icard, S Shulman, D Farhat, JM Steyaert… - Drug Resistance …, 2018 - Elsevier
Cancer cells employ both conventional oxidative metabolism and glycolytic anaerobic
metabolism. However, their proliferation is marked by a shift towards increasing glycolytic …

Flavonoids against the Warburg phenotype—Concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism

M Samec, A Liskova, L Koklesova, SM Samuel, K Zhai… - Epma Journal, 2020 - Springer
The Warburg effect is characterised by increased glucose uptake and lactate secretion in
cancer cells resulting from metabolic transformation in tumour tissue. The corresponding …

Fumarate hydratase in cancer: A multifaceted tumour suppressor

C Schmidt, M Sciacovelli, C Frezza - Seminars in cell & developmental …, 2020 - Elsevier
Cancer is now considered a multifactorial disorder with different aetiologies and outcomes.
Yet, all cancers share some common molecular features. Among these, the reprogramming …

Role of metabolic reprogramming in epithelial–mesenchymal transition (EMT)

H Kang, H Kim, S Lee, HS Youn, BH Youn - International Journal of …, 2019 - mdpi.com
Activation of epithelial–mesenchymal transition (EMT) is thought to be an essential step for
cancer metastasis. Tumor cells undergo EMT in response to a diverse range of extra-and …

AMPK: a balancer of the renin–angiotensin system

J Liu, X Li, Q Lu, D Ren, X Sun, T Rousselle… - Bioscience …, 2019 - portlandpress.com
The renin–angiotensin system (RAS) is undisputedly well-studied as one of the oldest and
most critical regulators for arterial blood pressure, fluid volume, as well as renal function. In …

Analysis of lncRNA-associated ceRNA network reveals potential lncRNA biomarkers in human colon adenocarcinoma

Z Zhang, W Qian, S Wang, D Ji, Q Wang, J Li… - Cellular Physiology and …, 2018 - karger.com
Abstract Background/Aims: Long non-coding RNAs (lncRNAs) acting as competing
endogenous RNAs (ceRNAs) play significant roles in the development of tumors, but the …

Unraveling the anticancer effect of curcumin and resveratrol

AR Pavan, GDB Silva, DH Jornada, DE Chiba… - Nutrients, 2016 - mdpi.com
Resveratrol and curcumin are natural products with important therapeutic properties useful
to treat several human diseases, including cancer. In the last years, the number of studies …