The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits,
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …

Abstract The RNA polymerase II (Pol II) pre-initiation complex (PIC) is a critical node in
eukaryotic transcription regulation, and its formation is the major rate-limiting step in …

Alterations in the regulation of gene expression are frequently associated with
developmental diseases or cancer. Transcription activation is a key phenomenon in the …

Enhancers can regulate the promoters of their target genes over very large genomic
distances. It is widely assumed that mechanisms of enhancer action involve the …

Eukaryotic transcription requires the assembly of a multisubunit preinitiation complex (PIC)
composed of RNA polymerase II (Pol II) and the general transcription factors. The coactivator …

Abstract The RNA polymerase II (Pol II) enzyme transcribes all protein-coding and most non-
coding RNA genes and is globally regulated by Mediator—a large, conformationally flexible …

The prevailing view of metazoan gene regulation is that transcription is facilitated through
the formation of static activator complexes at distal regulatory regions. Here, we employed …

The Mediator complex is a multi-subunit assembly that appears to be required for regulating
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …

The multisubunit Mediator, comprising∼ 30 distinct proteins, plays an essential role in gene
expression regulation by acting as a bridge between DNA-binding transcription factors and …

Abstract The PHYTOCHROME AND FLOWERING TIME1 gene encoding the MEDIATOR25
(MED25) subunit of the eukaryotic Mediator complex is a positive regulator of jasmonate …