Glycosylated proteins account for a majority of the posttranslation modifications of cell
surface, secreted, and circulating proteins. Within the tumor microenvironment, the presence …

Conspectus The structural boundaries of living cells are composed of numerous membrane-
forming lipids. Lipids not only are crucial for the cellular compartmentalization but also are …

MALDI mass spectrometry imaging is able to simultaneously determine the spatial
distribution of hundreds of molecules directly from tissue sections, without labeling and …

Purpose Most cancer-related deaths worldwide are associated with lung cancer. Subtyping
of non-small cell lung cancer (NSCLC) into adenocarcinoma (AC) and squamous cell …

We report a method for the unambiguous identification of molecules in biological and
materials specimens at high practical lateral resolution using a new TOF-SIMS parallel …

AMP-activated protein kinase (AMPK) is suppressed in diabetes and may be due to a high
ATP/AMP ratio, however the quantitation of nucleotides in vivo has been extremely difficult …

Alzheimer's disease (AD) is an aging-related neurodegenerative disease, leading to the
progressive loss of memory and other cognitive functions. As there is still no cure for AD, the …

Epidemiological studies indicate that patients with type 2 diabetes mellitus (T2DM) are at
increased risk of developing dementia/Alzheimer's disease (AD). This review, which is …

Background Current methods to identify, classify, and predict tumor behavior mostly rely on
histology, immunohistochemistry, and molecular determinants. However, better predictive …

Neurological disease and disorders remain a large public health threat. Thus, research to
improve early detection and/or develop more effective treatment approaches are necessary …