Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC
JV Tarazona, D Court-Marques, M Tiramani… - Archives of …, 2017 - Springer
Glyphosate is the most widely used herbicide worldwide. It is a broad spectrum herbicide
and its agricultural uses increased considerably after the development of glyphosate …
and its agricultural uses increased considerably after the development of glyphosate …
[HTML][HTML] Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment
Cancer is a key public health concern, being the second leading cause of worldwide
morbidity and mortality after cardiovascular diseases. At the global level, cancer prevalence …
morbidity and mortality after cardiovascular diseases. At the global level, cancer prevalence …
A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing
D Basketter, H Clewell, I Kimber, A Rossi… - 2012 - wellbeingintlstudiesrepository.org
Systemic toxicity testing forms the cornerstone for the safety evaluation of substances.
Pressures to move from traditional animal models to novel technologies arise from various …
Pressures to move from traditional animal models to novel technologies arise from various …
[图书][B] The costs and benefits of animal experiments
A Knight - 2011 - Springer
A comprehensive review of recent scientific evidence examining the contributions of animal
experimentation to human healthcare. The book also explores toxicity prediction, animal use …
experimentation to human healthcare. The book also explores toxicity prediction, animal use …
Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity
H Ellinger-Ziegelbauer, J Aubrecht, JC Kleinjans… - Toxicology letters, 2009 - Elsevier
Specific genotoxic events such as gene mutations and/or chromosome damage are
considered hallmarks of cancer. The genotoxicity testing battery enables relatively simple …
considered hallmarks of cancer. The genotoxicity testing battery enables relatively simple …
Systematic reviews of animal experiments demonstrate poor human clinical and toxicological utility
A Knight - Alternatives to Laboratory Animals, 2007 - journals.sagepub.com
The assumption that animal models are reasonably predictive of human outcomes provides
the basis for their widespread use in toxicity testing and in biomedical research aimed at …
the basis for their widespread use in toxicity testing and in biomedical research aimed at …
Genotoxic impurities: from structural alerts to qualification
DJ Snodin - Organic process research & development, 2010 - ACS Publications
The presence of an in cerebro structural alert in a potential or actual impurity, most likely
arising as a byproduct or carried-over reagent or starting material, in a drug substance or …
arising as a byproduct or carried-over reagent or starting material, in a drug substance or …
Systematic reviews of animal experiments demonstrate poor contributions toward human healthcare
A Knight - Reviews on recent clinical trials, 2008 - ingentaconnect.com
Widespread reliance on animal models during preclinical research and toxicity testing
assumes their reasonable predictivity for human outcomes. However, of 20 published …
assumes their reasonable predictivity for human outcomes. However, of 20 published …
[HTML][HTML] 3S–Systematic, systemic, and systems biology and toxicology
A biological system is more than the sum of its parts–it accomplishes many functions via
synergy. Deconstructing the system down to the molecular mechanism level necessitates …
synergy. Deconstructing the system down to the molecular mechanism level necessitates …
Ethical concerns of the veterinarian in relation to experimental animals and in vivo research
Ł Kiraga, A Dzikowski - Animals, 2023 - mdpi.com
Simple Summary The veterinarian's primary responsibility is to safeguard animal health and
public health, guided by the motto “Sanitas animalium pro salute homini”(the health of …
public health, guided by the motto “Sanitas animalium pro salute homini”(the health of …