Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC

JV Tarazona, D Court-Marques, M Tiramani… - Archives of …, 2017 - Springer
Glyphosate is the most widely used herbicide worldwide. It is a broad spectrum herbicide
and its agricultural uses increased considerably after the development of glyphosate …

[HTML][HTML] Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment

F Madia, A Worth, M Whelan, R Corvi - Environment international, 2019 - Elsevier
Cancer is a key public health concern, being the second leading cause of worldwide
morbidity and mortality after cardiovascular diseases. At the global level, cancer prevalence …

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing

D Basketter, H Clewell, I Kimber, A Rossi… - 2012 - wellbeingintlstudiesrepository.org
Systemic toxicity testing forms the cornerstone for the safety evaluation of substances.
Pressures to move from traditional animal models to novel technologies arise from various …

[图书][B] The costs and benefits of animal experiments

A Knight - 2011 - Springer
A comprehensive review of recent scientific evidence examining the contributions of animal
experimentation to human healthcare. The book also explores toxicity prediction, animal use …

Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity

H Ellinger-Ziegelbauer, J Aubrecht, JC Kleinjans… - Toxicology letters, 2009 - Elsevier
Specific genotoxic events such as gene mutations and/or chromosome damage are
considered hallmarks of cancer. The genotoxicity testing battery enables relatively simple …

Systematic reviews of animal experiments demonstrate poor human clinical and toxicological utility

A Knight - Alternatives to Laboratory Animals, 2007 - journals.sagepub.com
The assumption that animal models are reasonably predictive of human outcomes provides
the basis for their widespread use in toxicity testing and in biomedical research aimed at …

Genotoxic impurities: from structural alerts to qualification

DJ Snodin - Organic process research & development, 2010 - ACS Publications
The presence of an in cerebro structural alert in a potential or actual impurity, most likely
arising as a byproduct or carried-over reagent or starting material, in a drug substance or …

Systematic reviews of animal experiments demonstrate poor contributions toward human healthcare

A Knight - Reviews on recent clinical trials, 2008 - ingentaconnect.com
Widespread reliance on animal models during preclinical research and toxicity testing
assumes their reasonable predictivity for human outcomes. However, of 20 published …

[HTML][HTML] 3S–Systematic, systemic, and systems biology and toxicology

L Smirnova, N Kleinstreuer, R Corvi, A Levchenko… - Altex, 2018 - ncbi.nlm.nih.gov
A biological system is more than the sum of its parts–it accomplishes many functions via
synergy. Deconstructing the system down to the molecular mechanism level necessitates …

Ethical concerns of the veterinarian in relation to experimental animals and in vivo research

Ł Kiraga, A Dzikowski - Animals, 2023 - mdpi.com
Simple Summary The veterinarian's primary responsibility is to safeguard animal health and
public health, guided by the motto “Sanitas animalium pro salute homini”(the health of …