Metabolomics is a relatively new field of 'omics' technology that is primarily concerned with
the global or system-wide characterization of small molecule metabolites using technologies …

Tuberculosis (caused by Mycobacterium tuberculosis, Mtb) treatment involves multiple drug
regimens for a prolonged period. However, the therapeutic benefit is often limited by poor …

Background Tuberculosis still remains one of the largest killer infectious diseases,
warranting the identification of newer targets and drugs. Identification and validation of …

We aimed to characterize metabolites during tuberculosis (TB) disease and identify new
pathophysiologic pathways involved in infection as well as biomarkers of TB onset …

Background The increased sequencing of pathogen genomes and the subsequent
availability of genome-scale functional datasets are expected to guide the experimental …

With antibiotic resistance mechanisms increasing in diversity and spreading among
bacterial pathogens, the development of new classes of antibacterial agents against …

Profound tuberculosis (TB)-induced metabolic changes reflected in the blood metabolomic
profile may provide an opportunity to identify specific markers of Mycobacterium tuberculosis …

Mycobacterium abscessus, a non-tuberculous rapidly growing mycobacterium, is
recognized as an emerging human pathogen causing a variety of infections ranging from …

ATP-dependent Mur ligases (Mur synthetases) play essential roles in the biosynthesis of cell
wall peptidoglycan (PG) as they catalyze the ligation of key amino acid residues to the stem …

Objectives New anti-mycobacterial entities with novel mechanisms of action are clinically
needed for treating resistant forms of tuberculosis. The purpose of this study was to evaluate …