Five years of GWAS discovery

PM Visscher, MA Brown, MI McCarthy… - The American Journal of …, 2012 - cell.com
The past five years have seen many scientific and biological discoveries made through the
experimental design of genome-wide association studies (GWASs). These studies were …

Bioelectrical signals as emerging biometrics: Issues and challenges

YN Singh, SK Singh, AK Ray - International Scholarly Research …, 2012 - Wiley Online Library
This paper presents the effectiveness of bioelectrical signals such as the electrocardiogram
(ECG) and the electroencephalogram (EEG) for biometric applications. Studies show that …

Epidemiology and genetics of sudden cardiac death

R Deo, CM Albert - Circulation, 2012 - Am Heart Assoc
Sudden cardiac death (SCD) generally refers to an unexpected death from a cardiovascular
cause in a person with or without preexisting heart disease. The specificity of this definition …

Genome partitioning of genetic variation for complex traits using common SNPs

J Yang, TA Manolio, LR Pasquale, E Boerwinkle… - Nature …, 2011 - nature.com
We estimate and partition genetic variation for height, body mass index (BMI), von
Willebrand factor and QT interval (QTi) using 586,898 SNPs genotyped on 11,586 unrelated …

Several common variants modulate heart rate, PR interval and QRS duration

H Holm, DF Gudbjartsson, DO Arnar, G Thorleifsson… - Nature …, 2010 - nature.com
Electrocardiographic measures are indicative of the function of the cardiac conduction
system. To search for sequence variants that modulate heart rate, PR interval and QRS …

Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders

M Den Hoed, M Eijgelsheim, T Esko, BJJM Brundel… - Nature …, 2013 - nature.com
Elevated resting heart rate is associated with greater risk of cardiovascular disease and
mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 …

[HTML][HTML] Pacemaker channel dysfunction in a patient with sinus node disease

E Schulze-Bahr, A Neu, P Friederich… - The Journal of …, 2003 - Am Soc Clin Investig
The cardiac pacemaker current I f is a major determinant of diastolic depolarization in sinus
nodal cells and has a key role in heartbeat generation. Therefore, we hypothesized that …

Genome-and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk

MD Ritchie, JC Denny, RL Zuvich, DC Crawford… - Circulation, 2013 - Am Heart Assoc
Background—ECG QRS duration, a measure of cardiac intraventricular conduction, varies≈
2-fold in individuals without cardiac disease. Slow conduction may promote re-entrant …

Genome-wide association analysis identifies multiple loci related to resting heart rate

M Eijgelsheim, C Newton-Cheh… - Human molecular …, 2010 - academic.oup.com
Higher resting heart rate is associated with increased cardiovascular disease and mortality
risk. Though heritable factors play a substantial role in population variation, little is known …

[HTML][HTML] Evaluation of electrocardiogram for biometric authentication

YN Singh, SK Singh - 2011 - scirp.org
This paper presents an evaluation of a new biometric electrocardiogram (ECG) for individual
authentication. We report the potential of ECG as a biometric and address the research …