A riboswitch-driven era of new antibacterials
Riboswitches are structured non-coding RNAs found in the 5′ UTR of important genes for
bacterial metabolism, virulence and survival. Upon the binding of specific ligands that can …
bacterial metabolism, virulence and survival. Upon the binding of specific ligands that can …
Exploring the structure, function of thiamine pyrophosphate riboswitch, and designing small molecules for antibacterial activity
PD Wakchaure, B Ganguly - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
During the last decade, riboswitches emerged as new small‐molecule sensing RNA in
bacteria. Thiamine pyrophosphate (TPP) riboswitch is widely distributed and occurs in …
bacteria. Thiamine pyrophosphate (TPP) riboswitch is widely distributed and occurs in …
TPP Riboswitch Populates Holo-Form-like Structure Even in the Absence of Cognate Ligand at High Mg2+ Concentration
Riboswitches are noncoding RNA that regulate gene expression by folding into specific
three-dimensional structures (holo-form) upon binding by their cognate ligand in the …
three-dimensional structures (holo-form) upon binding by their cognate ligand in the …
Unraveling the role of π-stacking interactions in ligand binding to the thiamine pyrophosphate riboswitch with high-level quantum chemical calculations and docking …
PD Wakchaure, B Ganguly - The Journal of Physical Chemistry B, 2022 - ACS Publications
The thiamine pyrophosphate (TPP) riboswitch has emerged as the new target for designing
new ligands for antibiotic purpose. Binding of the natural ligand TPP to the TPP riboswitch …
new ligands for antibiotic purpose. Binding of the natural ligand TPP to the TPP riboswitch …
In silico investigation of riboswitches in fungi: structural and dynamical insights into TPP riboswitches in Aspergillus oryzae
V Vargas-Junior, D Antunes, AC Guimarães… - RNA biology, 2022 - Taylor & Francis
Riboswitches are RNA sensors affecting post-transcriptional processes through their ability
to bind to small molecules. Thiamine pyrophosphate (TPP) riboswitch plays a crucial role in …
to bind to small molecules. Thiamine pyrophosphate (TPP) riboswitch plays a crucial role in …
[PDF][PDF] 辅酶类核开关的种类, 结构和调控机制研究进展
许笑晨， 任艾明 - 自然杂志, 2024 - nature.shu.edu.cn
摘要核开关是一类保守的RNA 元件, 可以通过特异性识别小分子配体来开启或关闭下游相关
基因的表达, 进而调控细胞的生命活动. 目前已鉴定出近60 种核开关, 它们分别识别不同的代谢 …
基因的表达, 进而调控细胞的生命活动. 目前已鉴定出近60 种核开关, 它们分别识别不同的代谢 …
Riboswitches as Antimicrobial Targets
V Vargas-Junior, E Caffarena, D Antunes - Structure-Based Drug Design, 2024 - Springer
The spread of antibiotic-resistant bacteria represents a substantial health threat contributing
to morbidity and mortality worldwide. Current antibiotics act on a few metabolic pathways …
to morbidity and mortality worldwide. Current antibiotics act on a few metabolic pathways …
Research progress on the types, structures and regulation mechanisms of cofactor riboswitches# br
XU Xiaochen, REN Aiming - Chinese Journal of Nature, 2024 - nature.shu.edu.cn
Riboswitches are highly conserved RNA elements capable of recognizing small molecule
ligands and modulating downstream gene expression. To date, nearly 60 types of …
ligands and modulating downstream gene expression. To date, nearly 60 types of …
Influence of antimicrobial compounds and the RNA-binding protein RibR on the activity of B vitamin-responsive bacterial riboswitches
A Hübenthal - 2024 - archiv.ub.uni-heidelberg.de
Riboswitches are RNA elements that modulate the expression of genes involved in essential
metabolic pathways and occur mainly in the bacterial world. Binding of a specific small …
metabolic pathways and occur mainly in the bacterial world. Binding of a specific small …