The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

A considerable number of human diseases have an inflammatory component, and a key
mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS) …

Activated hepatic stellate cells (HSCs) and myofibroblasts are the main producers of
extracellular matrix (ECM) proteins that form the fibrotic tissue that leads to hepatic fibrosis …

Arginine (L-arginine), is an amino acid involved in a number of biological processes,
including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide …

Macrophages play a major role in the immune system, both as antimicrobial effector cells
and as immunoregulatory cells, which induce, suppress or modulate adaptive immune …

Nitric oxide (NO) is a gaseous reactive oxygen species (ROS) that has evolved as a
signaling hormone in many physiological processes in animals. In plants it has been …

This review concentrates on advances in nitric oxide synthase (NOS) structure, function and
inhibition made in the last seven years, during which time substantial advances have been …

Nitric oxide is an inorganic free radical gas, of formula* N= O (abbreviated as NO). The
discovery in 1987/88 that vascular endothelial cells are able to synthesize NO from L …

Three isozymes of nitric oxide (NO) synthase (EC 1.14. 13.39) have been identified and the
cDNAs for these enzymes isolated. In humans, isozymes I (in neuronal and epithelial cells) …

Purpose: To review the physiologic role of nitric oxide, an unusual messenger molecule that
mediates blood vessel relaxation, neurotransmission, and pathogen suppression. Data …