Biological effects of human exposure to environmental cadmium

M Peana, A Pelucelli, CT Chasapis, SP Perlepes… - Biomolecules, 2022 - mdpi.com
Cadmium (Cd) is a toxic metal for the human organism and for all ecosystems. Cd is
naturally found at low levels; however, higher amounts of Cd in the environment result from …

Selenoproteins and tRNA-Sec: regulators of cancer redox homeostasis

SL DeAngelo, B Győrffy, M Koutmos, YM Shah - Trends in Cancer, 2023 - cell.com
In the past two decades significant progress has been made in uncovering the biological
function of selenium. Selenium, an essential trace element, is required for the biogenesis of …

Thioredoxin 1 and Thioredoxin Reductase 1 Redox System Is Dysregulated in Neutrophils of Subjects with Autism: In Vitro Effects of Environmental Toxicant …

S Alshehri, SF Ahmad, NA Albekairi, SS Alqarni… - Toxics, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a complex developmental disorder in children that results
in abnormal communicative and verbal behaviors. Exposure to heavy metals plays a …

Study of the magnesium comenate structure, its neuroprotective and stress-protective activity

S Kozin, A Kravtsov, L Ivashchenko… - International Journal of …, 2023 - mdpi.com
The crystal structure and the biological activity of a new coordination compound of
magnesium ions with comenic acid, magnesium comenate, was characterized and studied …

Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway

S Gao, Q Cheng, Y Hu, X Fan, C Liang, C Niu… - Molecular and Cellular …, 2024 - Springer
This study aimed to explore the role of melatonin in oxidative stress-induced injury on retinal
ganglion cells and the underlying mechanisms. The immortalized RGC-5 cells were treated …

Disruption of Bacterial Thiol-Dependent Redox Homeostasis by Magnolol and Honokiol as an Antibacterial Strategy

Y Ouyang, X Tang, Y Zhao, X Zuo, X Ren, J Wang… - Antioxidants, 2023 - mdpi.com
Some traditional Chinese medicines (TCMs) possess various redox-regulation properties,
but whether the redox regulation contributes to antibacterial mechanisms is not known …

Auranofin Modulates Thioredoxin Reductase/Nrf2 Signaling in Peripheral Immune Cells and the CNS in a Mouse Model of Relapsing–Remitting EAE

LA Al-Kharashi, NO Al-Harbi, SF Ahmad, SM Attia… - Biomedicines, 2023 - mdpi.com
Multiple sclerosis (MS) is one of the most prevalent chronic inflammatory autoimmune
diseases. It causes the demyelination of neurons and the subsequent degeneration of the …

Icaritin greatly attenuates β‐amyloid‐induced toxicity in vivo

L Li, Z Wei, Y Tang, M Jin, H Yao, X Li… - CNS Neuroscience …, 2024 - Wiley Online Library
Aims The accumulation and deposition of β‐amyloid (Aβ) has always been considered a
major pathological feature of Alzheimer's disease (AD). The latest and mainstream amyloid …

Retinoic acid has neuroprotective effects by modulating thioredoxin in ischemic brain damage and glutamate-exposed neurons

JB Kang, PO Koh - Neuroscience, 2023 - Elsevier
Ischemic stroke is a neurological disorder that causes pathological changes by increasing
oxidative stress. Retinoic acid is one of the metabolites of vitamin A. It regulates oxidative …

Antiproliferative, antimigratory, and apoptotic effects of diffractaic and vulpinic acids as thioredoxin reductase 1 inhibitors on cervical cancer

B Budak, ŞN Kalın, ÖE Yapça - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
Cervical cancer is among the most frequently observed cancer types in females. New
therapeutic targets are needed because of the side impacts of existing cancer drugs and the …