Macropinocytosis is a form of endocytosis performed by ruffles and cups of the plasma
membrane. These close to entrap droplets of medium into micron-sized vesicles, which are …

The formation and processing of vesicles from the cell surface serves many important
cellular functions ranging from nutrient acquisition to regulating the turnover of membrane …

Macropinocytosis is a conserved endocytic process by which cells engulf droplets of
medium into micron-sized vesicles. We use light-sheet microscopy to define an underlying …

RasG is a major regulator of macropinocytosis in Dictyostelium discoideum. Its activity is
under the control of an IQGAP-related protein, IqgC, which acts as a RasG-specific GAP …

Amino acid transporters are expressed in mammalian cells not only in the plasma
membrane but also in intracellular membranes. The conventional function of these …

The volumes of a cell [cell volume (CV)] and its organelles are adjusted by osmoregulatory
processes. During pinocytosis, extracellular fluid volume equivalent to its CV is incorporated …

WIPIs are a conserved family of proteins with a characteristic 7-bladed β-propeller structure.
They play a prominent role in autophagy, but also in other membrane trafficking processes …

In fast-moving cells such as amoeba and immune cells, dendritic actin filaments are
spatiotemporally regulated to shape large-scale plasma membrane protrusions. Despite …

Macropinocytosis is a conserved endocytic process where cells take up medium into micron-
sized vesicles. In Dictyostelium, macropinocytic cups form around domains of PIP3 in the …

Multispectral imaging is an established method to extend the number of colours usable in
fluorescence imaging beyond the typical limit of three or four, but standard approaches are …