Metabologenomics integrates metabolomics with other omics data types to comprehensively
study the genetic and environmental factors that influence metabolism. These multi-omics …

Cancer is the second leading cause of death worldwide and disease burden is expected to
increase globally throughout the next several decades, with the majority of cancer-related …

Although genomic anomalies in glioblastoma (GBM) have been well studied for over a
decade, its 5-year survival rate remains lower than 5%. We seek to expand the molecular …

Neural–tumor interactions drive glioma growth as evidenced in preclinical models, but
clinical validation is limited. We present an epigenetically defined neural signature of …

In the past decade, remarkable progress in cancer medicine has been achieved by the
development of treatments that target DNA sequence variants. However, a purely genetic …

To study the spatial interactions among cancer and non-cancer cells 1, we here examined a
cohort of 131 tumour sections from 78 cases across 6 cancer types by Visium spatial …

Although cancer initiation and progression are generally associated with the accumulation
of somatic mutations,, substantial epigenomic alterations underlie many aspects of …

The proper use of spike-in normalization in ChIP-seq improves sensitivity for detecting
genome-wide changes between conditions, but improper use is common, calling some …

Reprogramming of methionine metabolism is a conserved hallmark of tumorigenesis.
Recent studies have revealed mechanisms regulating methionine metabolism within the …

Background Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in
tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational …