Complex genetic mechanisms are thought to underlie many human diseases, yet
experimental proof of this model has been elusive. Here, we show that a human cardiac …

MEF2C is a member of the highly conserved MEF2 family of transcription factors and is a key
regulator of cardiovascular development. In mice, Mef2c is expressed in the developing …

Endothelial and erythropoietic lineages arise from a common developmental progenitor.
Etv2 is a master transcriptional regulator required for the development of both lineages …

Myocardin (MYOCD) is the founding member of a class of transcriptional coactivators that
bind the serum-response factor to activate gene expression programs critical in smooth …

Pathological cardiac remodeling is induced through multiple mechanisms that include
neurohumoral and biomechanical stress resulting in transcriptional alterations that ultimately …

Abstract Class IIa Histone deacetylases (HDACs), including HDAC4, 5, 7 and 9, play key
roles in multiple important developmental and differentiation processes. Recent studies …

[目的] 克隆青海湖裸鲤慢收缩骨骼肌型肌钙蛋白I 基因(TNNI1) 和快收缩骨骼肌型肌钙蛋白I
基因(TNNI2), 分析其在不同组织及盐碱胁迫环境下皮肤和腹侧肌肉组织中的表达水平 …

Cardiac apoptosis has been identified as one of the main precipitating factors of heart failure
(HF) throughout the whole course of progressive disease. Limited to the lack of diagnostic …

Isoproterenol (ISO), a chemically synthesized catecholamine, belongs to β-adrenoceptor
agonist used to treat bradycardia. The β-adrenergic agonist is an essential regulator of …

Myocardial remodelling is a common phenomenon in cardiovascular diseases, which
threaten human health and the quality of life. Due to the lack of effective early diagnosis and …