Structure, function and pathophysiology of protease activated receptors
Discovered in the 1990s, protease activated receptors 1 (PARs) are membrane-spanning
cell surface proteins that belong to the G protein coupled receptor (GPCR) family. A defining …
cell surface proteins that belong to the G protein coupled receptor (GPCR) family. A defining …
[HTML][HTML] The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases
PJ Wermuth, SA Jimenez - Clinical and translational medicine, 2015 - Springer
The systemic and organ-specific human fibrotic disorders collectively represent one of the
most serious health problems world-wide causing a large proportion of the total world …
most serious health problems world-wide causing a large proportion of the total world …
Rebalanced hemostasis in patients with liver disease: evidence and clinical consequences
T Lisman, RJ Porte - Blood, The Journal of the American …, 2010 - ashpublications.org
Patients with liver disease frequently acquire a complex disorder of hemostasis secondary to
their disease. Routine laboratory tests such as the prothrombin time and the platelet count …
their disease. Routine laboratory tests such as the prothrombin time and the platelet count …
Enoxaparin reduces hepatic vascular resistance and portal pressure in cirrhotic rats
F Cerini, M Vilaseca, E Lafoz, O García-Irigoyen… - Journal of …, 2016 - Elsevier
Background & Aims Increased hepatic vascular resistance due to fibrosis and elevated
hepatic vascular tone is the primary factor in the development of portal hypertension …
hepatic vascular tone is the primary factor in the development of portal hypertension …
[PDF][PDF] Regulation of hepatic stellate cells by connective tissue growth factor
G Huang, DR Brigstock - Front Biosci (Landmark Ed), 2012 - josorge.com
Introduction 3. CTGF/CCN2 and fibrosis 4. CTGF/CCN2 production in fibrotic liver 5.
CTGF/CCN2 production by HSC 6. Regulation of CTGF/CCN2 mRNA expression in HSC 7 …
CTGF/CCN2 production by HSC 6. Regulation of CTGF/CCN2 mRNA expression in HSC 7 …
[HTML][HTML] Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model
Background & Aims Sinusoidal obstruction syndrome (SOS) following oxaliplatin based
chemotherapy can have a significant impact on post-operative outcome following resection …
chemotherapy can have a significant impact on post-operative outcome following resection …
Protease-activated receptors in kidney diseases: A comprehensive review of pathological roles, therapeutic outcomes and challenges
Studies have demonstrated that protease-activated receptors (PARs) with four subtypes
(PAR1-4) are mainly expressed in the renal epithelial, endothelial, and podocyte cells …
(PAR1-4) are mainly expressed in the renal epithelial, endothelial, and podocyte cells …
Role of the blood coagulation cascade in hepatic fibrosis
A Pant, AK Kopec, JP Luyendyk - American Journal of …, 2018 - journals.physiology.org
Liver is the primary source of numerous proteins that are critical for normal function of the
blood coagulation cascade. Because of this, diseases of the liver, particularly when affiliated …
blood coagulation cascade. Because of this, diseases of the liver, particularly when affiliated …
[HTML][HTML] Coagulation, microenvironment and liver fibrosis
Fibrosis is the main consequence of any kind of chronic liver damage. Coagulation and
thrombin generation are crucial in the physiological response to tissue injury; however, the …
thrombin generation are crucial in the physiological response to tissue injury; however, the …
[PDF][PDF] Protease‐activated receptor 2 promotes experimental liver fibrosis in mice and activates human hepatic stellate cells
V Knight, J Tchongue, D Lourensz, P Tipping… - …, 2012 - Wiley Online Library
Abstract Protease‐activated receptor (PAR) 2 is a G‐protein–coupled receptor that is
activated after proteolytic cleavage by serine proteases, including mast cell tryptase and …
activated after proteolytic cleavage by serine proteases, including mast cell tryptase and …