Discovered in the 1990s, protease activated receptors 1 (PARs) are membrane-spanning
cell surface proteins that belong to the G protein coupled receptor (GPCR) family. A defining …

The systemic and organ-specific human fibrotic disorders collectively represent one of the
most serious health problems world-wide causing a large proportion of the total world …

Patients with liver disease frequently acquire a complex disorder of hemostasis secondary to
their disease. Routine laboratory tests such as the prothrombin time and the platelet count …

Background & Aims Increased hepatic vascular resistance due to fibrosis and elevated
hepatic vascular tone is the primary factor in the development of portal hypertension …

Introduction 3. CTGF/CCN2 and fibrosis 4. CTGF/CCN2 production in fibrotic liver 5.
CTGF/CCN2 production by HSC 6. Regulation of CTGF/CCN2 mRNA expression in HSC 7 …

Background & Aims Sinusoidal obstruction syndrome (SOS) following oxaliplatin based
chemotherapy can have a significant impact on post-operative outcome following resection …

Studies have demonstrated that protease-activated receptors (PARs) with four subtypes
(PAR1-4) are mainly expressed in the renal epithelial, endothelial, and podocyte cells …

Liver is the primary source of numerous proteins that are critical for normal function of the
blood coagulation cascade. Because of this, diseases of the liver, particularly when affiliated …

Fibrosis is the main consequence of any kind of chronic liver damage. Coagulation and
thrombin generation are crucial in the physiological response to tissue injury; however, the …

Abstract Protease‐activated receptor (PAR) 2 is a G‐protein–coupled receptor that is
activated after proteolytic cleavage by serine proteases, including mast cell tryptase and …