A broad working definition of structural proteomics (SP) is that it is the process of the high-
throughput characterization of the three-dimensional structures of biological …

Tyrosine catabolism is an essential pathway in animals, but its role in plants is unclear. The
first steps of tyrosine degradation lead to the formation of homogentisate. In animals this is …

A prevalent side-reaction of succinate dehydrogenase oxidizes malate to enol-oxaloacetate
(OAA), a metabolically inactive form of OAA that is a strong inhibitor of succinate …

Leber's hereditary optic neuropathy (LHON) is a maternally transmitted disease caused by
mitochondria DNA (mtDNA) mutation. It is characterized by acute and subacute visual loss …

Background The availability of suitable recombinant protein is still a major bottleneck in
protein structure analysis. The Protein Structure Factory, part of the international structural …

The proper functioning of mitochondria requires that both the mitochondrial and the nuclear
genome are functional. To investigate the importance of the mitochondrial genome, which …

Fumarylacetoacetate hydrolase (FAH) domain-containing proteins occur in both prokaryotes
and eukaryotes, where they carry out diverse enzymatic reactions, probably related to …

Fumarylacetoacetate hydrolase (FAH) proteins form a superfamily found in Archaea,
Bacteria, and Eukaryota. However, few fumarylacetoacetate hydrolase domain (FAHD) …

The human fumarylacetoacetate hydrolase (FAH) domain-containing protein 1 (FAHD1) is
part of the FAH protein superfamily, but its enzymatic function is unknown. In the quest for a …

The archaeon Sulfolobus solfataricus converts d-arabinose to 2-oxoglutarate by an enzyme
set consisting of two dehydrogenases and two dehydratases. The third step of the pathway …