Environmental exposure during pregnancy: influence on prenatal development and early life: a comprehensive review
MD Gómez-Roig, R Pascal, MJ Cahuana… - Fetal diagnosis and …, 2021 - karger.com
Preconception and prenatal exposure to environmental contaminants may affect future
health. Pregnancy and early life are critical sensitive windows of susceptibility. The aim of …
health. Pregnancy and early life are critical sensitive windows of susceptibility. The aim of …
Oxidative stress as a common key event in developmental neurotoxicity
Y Nishimura, Y Kanda, H Sone… - Oxidative medicine and …, 2021 - Wiley Online Library
The developing brain is extremely sensitive to many chemicals. Perinatal exposure to
neurotoxicants has been implicated in several neurodevelopmental disorders, including …
neurotoxicants has been implicated in several neurodevelopmental disorders, including …
Fetal exposure to environmental chemicals; insights from placental perfusion studies
L Mathiesen, T Buerki-Thurnherr, J Pastuschek… - Placenta, 2021 - Elsevier
Introduction The burden of environmental chemicals in the human population is ubiquitous
and especially problematic in pregnancy due to potential exposure of the vulnerable fetus …
and especially problematic in pregnancy due to potential exposure of the vulnerable fetus …
Drug dosing in pregnant women: challenges and opportunities in using physiologically based pharmacokinetic modeling and simulations
AB Ke, R Greupink, K Abduljalil - CPT: pharmacometrics & …, 2018 - Wiley Online Library
The unmet medical need of providing evidence‐based pharmacotherapy for pregnant
women is recognized by the regulatory bodies. Physiologically based pharmacokinetic …
women is recognized by the regulatory bodies. Physiologically based pharmacokinetic …
Effects of cannabis tetrahydrocannabinol on endocannabinoid homeostasis in human placenta
Cannabis use has become a hot topic in several countries due to the debate about its
legalization for medical purposes. However, data are limited regarding adverse events …
legalization for medical purposes. However, data are limited regarding adverse events …
Equilibrative nucleoside transporter 1 (ENT1, SLC29A1) facilitates transfer of the antiretroviral drug abacavir across the placenta
Abacavir is a preferred antiretroviral drug for preventing mother-to-child human
immunodeficiency virus transmission; however, mechanisms of its placental transfer have …
immunodeficiency virus transmission; however, mechanisms of its placental transfer have …
The cannabinoid delta-9-tetrahydrocannabinol disrupts estrogen signaling in human placenta
Cannabis consumption is increasing worldwide either for recreational or medical purposes.
Its use during gestation is associated with negative pregnancy outcomes such as …
Its use during gestation is associated with negative pregnancy outcomes such as …
Ex vivo dual perfusion of the human placenta: disease simulation, therapeutic pharmacokinetics and analysis of off-target effects
In recent years ex vivo dual perfusion of the human placental lobule is seeing an
international renaissance in its application to understanding fetal health and development …
international renaissance in its application to understanding fetal health and development …
[HTML][HTML] Fetoplacental vascular effects of maternal adrenergic antihypertensive and cardioprotective medications in pregnancy
T Tropea, W Mavichak, A Evangelinos… - Journal of …, 2023 - journals.lww.com
Maternal cardiovascular diseases, including hypertension and cardiac conditions, are
associated with poor fetal outcomes. A range of adrenergic antihypertensive and …
associated with poor fetal outcomes. A range of adrenergic antihypertensive and …
Placental Drug Delivery to Treat Pre‐Eclampsia and Fetal Growth Restriction
Pre‐eclampsia and fetal growth restriction (FGR) continue to cause unacceptably high levels
of morbidity and mortality, despite significant pharmaceutical and technological advances in …
of morbidity and mortality, despite significant pharmaceutical and technological advances in …