Environmental exposure during pregnancy: influence on prenatal development and early life: a comprehensive review

MD Gómez-Roig, R Pascal, MJ Cahuana… - Fetal diagnosis and …, 2021 - karger.com
Preconception and prenatal exposure to environmental contaminants may affect future
health. Pregnancy and early life are critical sensitive windows of susceptibility. The aim of …

Oxidative stress as a common key event in developmental neurotoxicity

Y Nishimura, Y Kanda, H Sone… - Oxidative medicine and …, 2021 - Wiley Online Library
The developing brain is extremely sensitive to many chemicals. Perinatal exposure to
neurotoxicants has been implicated in several neurodevelopmental disorders, including …

Fetal exposure to environmental chemicals; insights from placental perfusion studies

L Mathiesen, T Buerki-Thurnherr, J Pastuschek… - Placenta, 2021 - Elsevier
Introduction The burden of environmental chemicals in the human population is ubiquitous
and especially problematic in pregnancy due to potential exposure of the vulnerable fetus …

Drug dosing in pregnant women: challenges and opportunities in using physiologically based pharmacokinetic modeling and simulations

AB Ke, R Greupink, K Abduljalil - CPT: pharmacometrics & …, 2018 - Wiley Online Library
The unmet medical need of providing evidence‐based pharmacotherapy for pregnant
women is recognized by the regulatory bodies. Physiologically based pharmacokinetic …

Effects of cannabis tetrahydrocannabinol on endocannabinoid homeostasis in human placenta

J Maia, L Midão, SC Cunha, M Almada… - Archives of …, 2019 - Springer
Cannabis use has become a hot topic in several countries due to the debate about its
legalization for medical purposes. However, data are limited regarding adverse events …

Equilibrative nucleoside transporter 1 (ENT1, SLC29A1) facilitates transfer of the antiretroviral drug abacavir across the placenta

L Cerveny, Z Ptackova, M Ceckova, R Karahoda… - Drug Metabolism and …, 2018 - ASPET
Abacavir is a preferred antiretroviral drug for preventing mother-to-child human
immunodeficiency virus transmission; however, mechanisms of its placental transfer have …

The cannabinoid delta-9-tetrahydrocannabinol disrupts estrogen signaling in human placenta

J Maia, M Almada, L Midão, BM Fonseca… - Toxicological …, 2020 - academic.oup.com
Cannabis consumption is increasing worldwide either for recreational or medical purposes.
Its use during gestation is associated with negative pregnancy outcomes such as …

Ex vivo dual perfusion of the human placenta: disease simulation, therapeutic pharmacokinetics and analysis of off-target effects

P Brownbill, N Sebire, EV McGillick, S Ellery… - … : Methods and Protocols, 2018 - Springer
In recent years ex vivo dual perfusion of the human placental lobule is seeing an
international renaissance in its application to understanding fetal health and development …

[HTML][HTML] Fetoplacental vascular effects of maternal adrenergic antihypertensive and cardioprotective medications in pregnancy

T Tropea, W Mavichak, A Evangelinos… - Journal of …, 2023 - journals.lww.com
Maternal cardiovascular diseases, including hypertension and cardiac conditions, are
associated with poor fetal outcomes. A range of adrenergic antihypertensive and …

Placental Drug Delivery to Treat Pre‐Eclampsia and Fetal Growth Restriction

V Deepak, L El‐Balawi, LK Harris - Small, 2024 - Wiley Online Library
Pre‐eclampsia and fetal growth restriction (FGR) continue to cause unacceptably high levels
of morbidity and mortality, despite significant pharmaceutical and technological advances in …