The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk

K Maiese - Frontiers in immunology, 2023 - frontiersin.org
Life expectancy is increasing throughout the world and coincides with a rise in non-
communicable diseases (NCDs), especially for metabolic disease that includes diabetes …

Unraveling the Link between Olfactory Deficits and Neuropsychiatric Disorders

K Yang, C Ayala-Grosso, JP Bhattarai… - Journal of …, 2023 - Soc Neuroscience
Smell loss has caught public attention during the recent COVID-19 pandemic. Research on
olfactory function in health and disease gains new momentum. Smell deficits have long …

[HTML][HTML] Proteome-wide analysis identifies plasma immune regulators of amyloid-beta progression

MR Duggan, GT Gomez, CM Joynes, M Bilgel… - Brain, Behavior, and …, 2024 - Elsevier
While immune function is known to play a mechanistic role in Alzheimer's disease (AD),
whether immune proteins in peripheral circulation influence the rate of amyloid-β (Aβ) …

[HTML][HTML] Traffic-related ultrafine particles impair mitochondrial functions in human olfactory mucosa cells–Implications for Alzheimer's disease

L Mussalo, R Lampinen, S Avesani, T Závodná… - Redox biology, 2024 - Elsevier
Constituents of air pollution, the ultrafine particles (UFP) with a diameter of≤ 0.1 μm, are
considerably related to traffic emissions. Several studies link air pollution to Alzheimer's …

[HTML][HTML] Exposure to urban particulate matter alters responses of olfactory mucosal cells to SARS-CoV-2 infection

MA Shahbaz, S Kuivanen, L Mussalo, AM Afonin… - Environmental …, 2024 - Elsevier
Respiratory viruses have a significant impact on health, as highlighted by the COVID-19
pandemic. Exposure to air pollution can contribute to viral susceptibility and be associated …

Inflammation-related pathology in the olfactory epithelium: its impact on the olfactory system in psychotic disorders

K Yang, Y Hasegawa, JP Bhattarai, J Hua… - Molecular …, 2024 - nature.com
Smell deficits and neurobiological changes in the olfactory bulb (OB) and olfactory
epithelium (OE) have been observed in schizophrenia and related disorders. The OE is the …

Neuropathological stage‐dependent proteome mapping of the olfactory tract in Alzheimer's disease: From early olfactory‐related omics signatures to computational …

P Cartas‐Cejudo, A Cortés, M Lachén‐Montes… - Brain …, 2024 - Wiley Online Library
Alzheimer's disease (AD) is the most common form of dementia, characterized by an early
olfactory dysfunction, progressive memory loss, and behavioral deterioration. Albeit …

A review and analysis of key biomarkers in Alzheimer's disease

Z Zhang, X Liu, S Zhang, Z Song, K Lu… - Frontiers in …, 2024 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects over 50
million elderly individuals worldwide. Although the pathogenesis of AD is not fully …

Olfactory neuroepithelium-derived cellular models to study neurological and psychiatric disorders

K Yang, OV Evgrafov - Frontiers in Neuroscience, 2023 - frontiersin.org
Neurodevelopment is a spatially and temporally regulated process that occurs mostly during
the embryonic and fetal stages. Given the sophistication of the nervous system, particularly …

Alzheimer's proteinopathy in olfactory neuroepithelium from persistent olfactory impairment SARS-CoV-2 patients

CAA Grosso, R Pieruzzini, C Rodriguez, M Gil… - Authorea …, 2024 - techrxiv.org
Persistent olfactory impairment (POI) and dysgeusia are lingering symptoms following
recovery from Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection. These …