Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of
cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85 …

Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain
cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts …

Malignant tumors, including colorectal cancer (CRC), usually rely on ATP generation
through aerobic glycolysis for both rapid growth and chemotherapy resistance. The M2 …

Simple Summary The deregulation of the oxidative metabolism in cancer cells,
characterized by an increased ratio between glycolysis and oxygen consumption (Warburgv …

The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …

Hypoxia is commonly observed in solid tumors and contributes to the resistance of DNA
damage drugs. However, the mechanisms behind this resistance are still unclear. In this …

Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different
subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly …

The ketone bodies (KBs) β-hydroxybutyrate and acetoacetate are important alternative
energy sources for glucose during nutrient deprivation. KBs synthesized by hepatic …

Background Hepatocellular carcinoma (HCC) is a common primary malignant tumor which
usually progresses to an advanced stage because of late diagnosis. Sorafenib (Sora) is a …

Abstract N6-methyladenosine (m6A) acts as the most common mRNA modification in
mammal cells. Fat Mass and Obesity-associated protein (FTO) is the firstly identified …