The enormous diversity of proteoforms produces tremendous complexity within cellular
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …

In 1976, I (JTC) finished my psychiatric residency, received my first National Institutes of
Health grant, opened my laboratory, and took responsibility for the Schizophrenia Outpatient …

Synaptic neurotransmission relies on maintenance of the synapse and meeting the energy
demands of neurons. Defects in excitatory and inhibitory synapses have been implicated in …

On observing schizophrenia from a clinical point of view up to its molecular basis, one may
conclude that this is likely to be one of the most complex human disorders to be …

The advances in mass spectrometry based proteomics in the past 15 years have contributed
to a deeper appreciation of protein networks and the composition of functional synaptic …

Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with strong
genetic heterogeneity and more prevalent in males than females. Recent human genetic …

Abstract Lysine-specific demethylase 1 (LSD1) is an enzyme that demethylates methylated
histone H3 lysine 4 (H3K4). Inhibition of LSD1 enzyme activity could increase H3K4 …

We utilized a cell-level approach to examine glycolytic pathways in the DLPFC of subjects
with schizophrenia (n= 16) and control (n= 16) and found decreased mRNA expression of …

Dysregulation of histone H3 lysine 4 (H3K4) methylation has been implicated in the
pathogenesis of several neurodevelopmental disorders. Targeting lysine-specific …

N-methyl-D-aspartate receptors (NMDARs) are required to shape activity-dependent
connections in the developing and adult brain. Impaired NMDAR signalling through genetic …