Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system
indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of …

The expression of CD4 and CD8 co-receptors defines two distinct T cell populations with
specialized functions. While CD4+ T cells support and modulate immune responses through …

The clinical successes of immune checkpoint blockade (ICB) in advanced cancer patients
have recently spurred the clinical implementation of ICB in the neoadjuvant and …

Cancer cells favor the generation of myeloid cells with immunosuppressive and
inflammatory features, including myeloid-derived suppressor cells (MDSCs), which support …

The thymus gland is a central lymphoid organ in which developing T cell precursors, known
as thymocytes, undergo differentiation into distinct type of mature T cells, ultimately migrating …

Despite advances in targeted therapies and immunotherapy in lung cancer, chemotherapy
remains the backbone of treatment in most patients at different stages of the disease …

Background Narcolepsy Type I (NT1) is a rare, life-long sleep disorder arising as a
consequence of the extensive destruction of orexin-producing hypothalamic neurons. The …

Introduction Vitiligo is an acquired de-pigmentation disorder characterized by the post-natal
loss of epidermal melanocytes (pigment-producing cells) resulting in the appearance of …

The small G protein Arf1 has been identified as playing a selective role in supporting cancer
stem cells (CSCs), making it an attractive target for cancer therapy. However, the current Arf1 …

We present TopicFlow, a computational framework for flow cytometry data analysis of patient
blood samples for the identification of functional and dynamic topics in circulating T cell …