[HTML][HTML] Insulators and domains of gene expression
T Ali, R Renkawitz, M Bartkuhn - Current opinion in genetics & …, 2016 - Elsevier
The genomic organization into active and inactive chromatin domains imposes specific
requirements for having domain boundaries to prohibit interference between the opposing …
requirements for having domain boundaries to prohibit interference between the opposing …
Mechanisms of Interaction between Enhancers and Promoters in Three Drosophila Model Systems
O Kyrchanova, V Sokolov, P Georgiev - International Journal of Molecular …, 2023 - mdpi.com
In higher eukaryotes, the regulation of developmental gene expression is determined by
enhancers, which are often located at a large distance from the promoters they regulate …
enhancers, which are often located at a large distance from the promoters they regulate …
[HTML][HTML] deepTools2: a next generation web server for deep-sequencing data analysis
We present an update to our Galaxy-based web server for processing and visualizing
deeply sequenced data. Its core tool set, deepTools, allows users to perform complete …
deeply sequenced data. Its core tool set, deepTools, allows users to perform complete …
High-resolution TADs reveal DNA sequences underlying genome organization in flies
Despite an abundance of new studies about topologically associating domains (TADs), the
role of genetic information in TAD formation is still not fully understood. Here we use our …
role of genetic information in TAD formation is still not fully understood. Here we use our …
ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters
Chromatin interactions connect distal regulatory elements to target gene promoters guiding
stimulus-and lineage-specific transcription. Few factors securing chromatin interactions have …
stimulus-and lineage-specific transcription. Few factors securing chromatin interactions have …
Sub-kb Hi-C in D. melanogaster reveals conserved characteristics of TADs between insect and mammalian cells
Topologically associating domains (TADs) are fundamental elements of the eukaryotic
genomic structure. However, recent studies suggest that the insulating complexes …
genomic structure. However, recent studies suggest that the insulating complexes …
Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer's disease mice
S Alves, G Churlaud, M Audrain… - Brain, 2017 - academic.oup.com
Abstract Interleukin-2 (IL-2)-deficient mice have cytoarchitectural hippocampal modifications
and impaired learning and memory ability reminiscent of Alzheimer's disease. IL-2 …
and impaired learning and memory ability reminiscent of Alzheimer's disease. IL-2 …
“Stripe” transcription factors provide accessibility to co-binding partners in mammalian genomes
Regulatory elements activate promoters by recruiting transcription factors (TFs) to specific
motifs. Notably, TF-DNA interactions often depend on cooperativity with colocalized …
motifs. Notably, TF-DNA interactions often depend on cooperativity with colocalized …
Essential role of Cp190 in physical and regulatory boundary formation
A Kaushal, J Dorier, B Wang, G Mohana… - Science …, 2022 - science.org
Boundaries in animal genomes delimit contact domains with enhanced internal contact
frequencies and have debated functions in limiting regulatory cross-talk between domains …
frequencies and have debated functions in limiting regulatory cross-talk between domains …
Active promoters give rise to false positive 'Phantom Peaks' in ChIP-seq experiments
Chromatin immunoprecipitation (ChIP) is widely used to identify chromosomal binding sites.
Chromatin proteins are cross-linked to their target sequences in living cells. The purified …
Chromatin proteins are cross-linked to their target sequences in living cells. The purified …