Plant toxic proteins: their biological activities, mechanism of action and removal strategies
E Kocyigit, B Kocaadam-Bozkurt, O Bozkurt… - Toxins, 2023 - mdpi.com
Plants evolve to synthesize various natural metabolites to protect themselves against
threats, such as insects, predators, microorganisms, and environmental conditions (such as …
threats, such as insects, predators, microorganisms, and environmental conditions (such as …
A critical review on role of available synthetic drugs and phytochemicals in insulin resistance treatment by targeting PTP1B
Insulin resistance (IR) is a condition of impaired response of cells towards insulin. It is
marked by excessive blood glucose, dysregulated insulin signalling, altered pathways …
marked by excessive blood glucose, dysregulated insulin signalling, altered pathways …
Identification of antidiabetic peptides derived from in silico hydrolysis of three ancient grains: Amaranth, Quinoa and Chia
FV Zamudio, SN Hidalgo-Figueroa, RRO Andrade… - Food Chemistry, 2022 - Elsevier
The antidiabetic potential of bioactive peptides derived from simulated gastrointestinal
digestion (SGID) of proteins present in amaranth quinoa and chia was evaluated using their …
digestion (SGID) of proteins present in amaranth quinoa and chia was evaluated using their …
Targeting the DENV NS2B-NS3 protease with active antiviral phytocompounds: structure-based virtual screening, molecular docking and molecular dynamics …
P Purohit, S Sahoo, M Panda, PS Sahoo… - Journal of Molecular …, 2022 - Springer
Dengue fever has been a global health concern. Mitigation is a challenging problem due to
non-availability of workable treatments. The most difficult objective is to design a perfect anti …
non-availability of workable treatments. The most difficult objective is to design a perfect anti …
Application of molecular dynamics simulation for exploring the roles of plant biomolecules in promoting environmental health
J Wu, T Gao, H Guo, L Zhao, S Lv, J Lv, R Yao… - Science of The Total …, 2023 - Elsevier
Understanding the dynamic changes of plant biomolecules is vital for exploring their
mechanisms in the environment. Molecular dynamics (MD) simulation has been widely used …
mechanisms in the environment. Molecular dynamics (MD) simulation has been widely used …
Advanced bioinformatics tools in the pharmacokinetic profiles of natural and synthetic compounds with anti-diabetic activity
AM Udrea, G Gradisteanu Pircalabioru, AA Boboc… - Biomolecules, 2021 - mdpi.com
Diabetes represents a major health problem, involving a severe imbalance of blood sugar
levels, which can disturb the nerves, eyes, kidneys, and other organs. Diabes management …
levels, which can disturb the nerves, eyes, kidneys, and other organs. Diabes management …
Bioactive compound identification and in vitro evaluation of antidiabetic and cytotoxic potential of Garcinia atroviridis fruit extract
With a continuous threat of type 2 diabetes mellitus (T2DM) worldwide, efforts to discover
new alternatives are ongoing for its management. Therefore, the use of natural herbal …
new alternatives are ongoing for its management. Therefore, the use of natural herbal …
Hypoglycemic activity of immature persimmon (Diospyros kaki Thunb.) extracts and its inhibition mechanism for α-amylase and α-glucosidase
Z Han, W Ren, X Liu, N Lin, J Qu, X Duan… - International Journal of …, 2024 - Elsevier
Persimmon tannins, particularly in immature persimmons, haven't yet received
corresponding attention to research on therapy of diabetes mellitus in spite of high …
corresponding attention to research on therapy of diabetes mellitus in spite of high …
Toward the identification of natural antiviral drug candidates against merkel cell polyomavirus: computational drug design approaches
Merkel cell carcinoma (MCC) is a rare form of aggressive skin cancer mainly caused by
Merkel cell polyomavirus (MCPyV). Most MCC tumors express MCPyV large T (LT) antigens …
Merkel cell polyomavirus (MCPyV). Most MCC tumors express MCPyV large T (LT) antigens …
Structural and functional analysis of disease-associated mutations in GOT1 gene: An in silico study
Disease-associated single nucleotide polymorphisms (SNPs) alter the natural functioning
and the structure of proteins. Glutamic-oxaloacetic transaminase 1 (GOT1) is a gene …
and the structure of proteins. Glutamic-oxaloacetic transaminase 1 (GOT1) is a gene …