The glymphatic hypothesis proposes a mechanism for extravascular transport into and out of
the brain of hydrophilic solutes unable to cross the blood–brain barrier. It suggests that there …

The blood-brain barrier (BBB) poses a unique challenge for drug delivery to the central
nervous system (CNS). The BBB consists of a continuous layer of specialized endothelial …

In vivo optogenetics and photopharmacology are two techniques for controlling neuronal
activity that have immense potential in neuroscience research. Their applications in tether …

Convection-enhanced delivery (CED) of cintredekin besudotox (CB) was compared with
Gliadel wafers (GW) in adult patients with glioblastoma multiforme (GBM) at first recurrence …

Convection-enhanced delivery (CED) is a promising technique that generates a pressure
gradient at the tip of an infusion catheter to deliver therapeutics directly through the …

Featuring contributions by leading researchers in the field, Nanoparticle Heat Transfer and
Fluid Flow explores heat transfer and fluid flow processes in nanomaterials and nanofluids …

Glioblastoma is the most common malignant brain tumor, and it carries an extremely poor
prognosis. Attempts to develop targeted therapies have been hindered because the blood …

Convection-enhanced delivery (CED) is a bulk flow–driven process. Its properties permit
direct, homogeneous, targeted perfusion of CNS regions with putative therapeutics while …

Significant progress has been made during the past decade towards the clinical adoption of
cell-based therapeutics. However, existing cell-delivery approaches have shown limited …

Digital twins employ mathematical and computational models to virtually represent a
physical object (eg, planes and human organs), predict the behavior of the object, and …