The administration of drugs to the central nervous system (CNS) is primarily controlled by
the blood-brain barrier (BBB), a structure that prevents the passage of foreign compounds …

Neuropsychiatric diseases are one of the main causes of disability, affecting millions of
people. Various drugs are used for its treatment, although no effective therapy has been …

Intranasal administration has gained an increasing interest for brain drug delivery since it
allows direct transport through neuronal pathways, which can be quite advantageous for …

Gliomas are the most malignant brain tumors, and their treatment is very challenging
because of the presence of the blood–brain barrier (BBB). Intranasal administration has …

This advanced review describes the anatomical and physiological barriers and mechanisms
impacting nanomedicine translocation from the nasal cavity directly to the brain. There are …

Depression, the second biggest cause of disability worldwide, is widespread. Many
antidepressant medications, including Desvenlafaxine Succinate (DVS), function by …

The present study was intended to prepare and optimize agomelatine-loaded
nanostructured lipid carriers (AGM-NLCs) for augmented in vivo antidepressant potential …

As a mental disease in modern society, depression shows an increasing occurrence, with
low cure rate and high recurrence rate. It has become the most disabling disease in the …

Background Dysbiosis or imbalance of gut microbiota in Alzheimer's disease (AD) affects the
production of short-chain fatty acids (SCFAs), whereas exogenous SCFAs supplementation …

Background Polysaccharides acceded by the Food and Drug Administration are among the
most exploitable polymers for fabricating nasally applied vehicles containing therapeutically …