Tumor suppressive protein phosphatases in human cancer: Emerging targets for therapeutic intervention and tumor stratification
B Meeusen, V Janssens - The international journal of biochemistry & cell …, 2018 - Elsevier
Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …
Deregulation of negative controls on TGF-β1 signaling in tumor progression
The multi-functional cytokine transforming growth factor-β1 (TGF-β1) has growth inhibitory
and anti-inflammatory roles during homeostasis and the early stages of cancer. Aberrant …
and anti-inflammatory roles during homeostasis and the early stages of cancer. Aberrant …
NPLC0393 from Gynostemma pentaphyllum ameliorates Alzheimer's disease‐like pathology in mice by targeting protein phosphatase magnesium‐dependent 1A …
J Lv, X Shen, X Shen, S Zhao, R Xu, Q Yan… - Phytotherapy …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disease with clinical hallmarks of
progressive cognitive impairment and memory loss. Gynostemma pentaphyllum ameliorates …
progressive cognitive impairment and memory loss. Gynostemma pentaphyllum ameliorates …
PPM1A regulates antiviral signaling by antagonizing TBK1-mediated STING phosphorylation and aggregation
Stimulator of interferon genes (STING, also known as MITA and ERIS) is critical in protecting
the host against DNA pathogen invasion. However, the molecular mechanism underlying …
the host against DNA pathogen invasion. However, the molecular mechanism underlying …
Interplay between SUMO1-related SUMOylation and phosphorylation of p65 promotes hepatocellular carcinoma progression
C Jiang, C Zhang, M Dai, F Wang, S Xu, D Han… - … et Biophysica Acta (BBA …, 2024 - Elsevier
The nuclear factor kappaB (NF-κB) subunit p65, plays an important role in the progression of
hepatocellular carcinoma (HCC). Phosphorylation of p65 is considered as an important …
hepatocellular carcinoma (HCC). Phosphorylation of p65 is considered as an important …
Cancer and necroptosis: friend or foe?
Regulated cell death is one major factor to ensure homoeostasis in multicellular organisms.
For decades, apoptosis was considered as the sole form of regulated cell death, whereas …
For decades, apoptosis was considered as the sole form of regulated cell death, whereas …
Natural flavone tricin exerted anti-inflammatory activity in macrophage via NF-κB pathway and ameliorated acute colitis in mice
XX Li, SG Chen, GGL Yue, HF Kwok, JKM Lee… - Phytomedicine, 2021 - Elsevier
Background Ulcerative colitis is a subtype of inflammatory bowel disease, characterized by
relapsing inflammation in the gastrointestinal tract with limited treatment options. Previous …
relapsing inflammation in the gastrointestinal tract with limited treatment options. Previous …
Infection reveals a modification of SIRT2 critical for chromatin association
JM Pereira, C Chevalier, T Chaze, Q Gianetto… - Cell Reports, 2018 - cell.com
Sirtuin 2 is a nicotinamide-adenine-dinucleotide-dependent deacetylase that regulates cell
processes such as carcinogenesis, cell cycle, DNA damage, and infection. Subcellular …
processes such as carcinogenesis, cell cycle, DNA damage, and infection. Subcellular …
TGF-β1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM
Background Hepatic stellate cell (HSC) activation induced by transforming growth factor β1
(TGF-β1) plays a pivotal role in fibrogenesis, while the complex downstream mediators of …
(TGF-β1) plays a pivotal role in fibrogenesis, while the complex downstream mediators of …
PPM1A silences cytosolic RNA sensing and antiviral defense through direct dephosphorylation of MAVS and TBK1
Cytosolic RNA sensing is a prerequisite for initiation of innate immune response against
RNA viral pathogens. Signaling through RIG-I (retinoic acid–inducible gene I)–like receptors …
RNA viral pathogens. Signaling through RIG-I (retinoic acid–inducible gene I)–like receptors …