Spontaneous subarachnoid haemorrhage

J Claassen, S Park - The Lancet, 2022 - thelancet.com
Subarachnoid haemorrhage (SAH) is the third most common subtype of stroke. Incidence
has decreased over past decades, possibly in part related to lifestyle changes such as …

Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies

BL Edlow, J Claassen, ND Schiff… - Nature Reviews Neurology, 2021 - nature.com
Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness

D Kondziella, A Bender, K Diserens… - European journal of …, 2020 - Wiley Online Library
Background and purpose Patients with acquired brain injury and acute or prolonged
disorders of consciousness (DoC) are challenging. Evidence to support diagnostic decisions …

[HTML][HTML] Detection of brain activation in unresponsive patients with acute brain injury

J Claassen, K Doyle, A Matory, C Couch… - … England Journal of …, 2019 - Mass Medical Soc
Background Brain activation in response to spoken motor commands can be detected by
electroencephalography (EEG) in clinically unresponsive patients. The prevalence and …

Clinical and advanced neurophysiology in the prognostic and diagnostic evaluation of disorders of consciousness: review of an IFCN-endorsed expert group

A Comanducci, M Boly, J Claassen, M De Lucia… - Clinical …, 2020 - Elsevier
The analysis of spontaneous EEG activity and evoked potentials is a cornerstone of the
instrumental evaluation of patients with disorders of consciousness (DoC). The past few …

Cognitive-motor dissociation and time to functional recovery in patients with acute brain injury in the USA: a prospective observational cohort study

J Egbebike, Q Shen, K Doyle… - The Lancet …, 2022 - thelancet.com
Background Recovery trajectories of clinically unresponsive patients with acute brain injury
are largely uncertain. Brain activation in the absence of a behavioural response to spoken …

Preservation of brain activity in unresponsive patients identifies MCS star

A Thibaut, R Panda, J Annen, LRD Sanz… - Annals of …, 2021 - Wiley Online Library
Objective Brain‐injured patients who are unresponsive at the bedside (ie, vegetative
state/unresponsive wakefulness syndrome–VS/UWS) may present brain activity similar to …

Therapies to restore consciousness in patients with severe brain injuries: a gap analysis and future directions

BL Edlow, LRD Sanz, L Polizzotto, N Pouratian… - Neurocritical care, 2021 - Springer
Abstract Background/Objective For patients with disorders of consciousness (DoC) and their
families, the search for new therapies has been a source of hope and frustration. Almost all …

Outcome prediction in patients with severe traumatic brain injury using deep learning from head CT scans

M Pease, D Arefan, J Barber, E Yuh, A Puccio… - Radiology, 2022 - pubs.rsna.org
Background After severe traumatic brain injury (sTBI), physicians use long-term
prognostication to guide acute clinical care yet struggle to predict outcomes in comatose …

Assessing the depth of language processing in patients with disorders of consciousness

P Gui, Y Jiang, D Zang, Z Qi, J Tan, H Tanigawa… - Nature …, 2020 - nature.com
Assessing residual consciousness and cognitive abilities in unresponsive patients is a major
clinical concern and a challenge for cognitive neuroscience. Although neuroimaging studies …